U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    KMT2A lysine methyltransferase 2A [ Equus caballus (horse) ]

    Gene ID: 100071238, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KMT2Aprovided by VGNC
    Official Full Name
    lysine methyltransferase 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:19493
    See related
    Ensembl:ENSECAG00000007743
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KMT2A in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 7 NC_009150.3 (26823114..26903602)

    Chromosome 7 - NC_009150.3Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ubiquitination factor E4A Neighboring gene ATP synthase membrane subunit g Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC102148748 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_009150.3 Chromosome 7 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    histone-lysine N-methyltransferase 2A
    Names
    Histone-lysine N-methyltransferase HRX-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009150.3 Reference EquCab3.0 Primary Assembly

      Range
      26823114..26903602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023644902.1 → XP_023500670.1  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      A0A5F5Q438
      Conserved Domains (11) summary
      cd05493
      Location:1682 → 1812
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3701 → 3784
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3863 → 3983
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3985 → 4001
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1180 → 1227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1659
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1906 → 2018
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2059 → 2106
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2136 → 2484
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_023644907.1 → XP_023500675.1  histone-lysine N-methyltransferase 2A isoform X6

      UniProtKB/TrEMBL
      A0A9L0R326
      Related
      ENSECAP00000056035.1, ENSECAT00000142437.1
      Conserved Domains (11) summary
      cd05493
      Location:1682 → 1812
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3435 → 3518
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3597 → 3717
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3719 → 3735
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1180 → 1227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1659
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1906 → 2018
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2059 → 2106
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2093 → 2484
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    3. XM_023644904.1 → XP_023500672.1  histone-lysine N-methyltransferase 2A isoform X3

      UniProtKB/TrEMBL
      A0A5F5Q438
      Related
      ENSECAP00000054822.2, ENSECAT00000075690.2
      Conserved Domains (11) summary
      cd05493
      Location:1679 → 1809
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3698 → 3781
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3860 → 3980
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3982 → 3998
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1180 → 1227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1656
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1903 → 2015
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2056 → 2103
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2133 → 2481
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    4. XM_023644903.1 → XP_023500671.1  histone-lysine N-methyltransferase 2A isoform X2

      UniProtKB/TrEMBL
      A0A5F5Q438
      Conserved Domains (11) summary
      cd05493
      Location:1681 → 1811
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3700 → 3783
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3862 → 3982
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3984 → 4000
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1180 → 1227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1561
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1599 → 1658
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1905 → 2017
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2058 → 2105
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2135 → 2483
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. XM_023644905.1 → XP_023500673.1  histone-lysine N-methyltransferase 2A isoform X4

      UniProtKB/TrEMBL
      F6U6A9
      Related
      ENSECAP00000006426.3, ENSECAT00000008563.3
      Conserved Domains (11) summary
      cd05493
      Location:1649 → 1779
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3668 → 3751
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3830 → 3950
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3952 → 3968
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1147 → 1194
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1626
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1873 → 1985
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2026 → 2073
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2103 → 2451
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    6. XM_023644906.1 → XP_023500674.1  histone-lysine N-methyltransferase 2A isoform X5

      UniProtKB/TrEMBL
      F6U6A9
      Conserved Domains (11) summary
      cd05493
      Location:1646 → 1776
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3665 → 3748
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3827 → 3947
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3949 → 3965
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1147 → 1194
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1623
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1870 → 1982
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2023 → 2070
      FYRN; F/Y-rich N-terminus
      cl25496
      Location:2100 → 2448
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.