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    Adissp adipose secreted signaling protein [ Mus musculus (house mouse) ]

    Gene ID: 67326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adisspprovided by MGI
    Official Full Name
    adipose secreted signaling proteinprovided by MGI
    Primary source
    MGI:MGI:1914576
    See related
    Ensembl:ENSMUSG00000027327 AllianceGenome:MGI:1914576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700037H04Rik
    Summary
    Predicted to enable protein phosphatase 1 binding activity. Involved in adaptive thermogenesis; glucose homeostasis; and positive regulation of protein kinase A signaling. Located in extracellular space. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and thymus. Orthologous to human ADISSP (adipose secreted signaling protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 276.7), mammary gland adult (RPKM 135.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adissp in Genome Data Viewer
    Location:
    2 F1; 2 63.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130988235..131002001, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131146315..131160085, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30378 Neighboring gene heat shock protein 12B Neighboring gene STARR-seq mESC enhancer starr_05701 Neighboring gene predicted gene 14232 Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Chen Q, et al. Nat Commun, 2022 Dec 10. PMID 36496438, Free PMC Article
    2. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adipose-secreted signaling protein
    Names
    UPF0687 protein C20orf27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311138.1 → NP_001298067.1  adipose-secreted signaling protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
      Source sequence(s)
      AK006622, AL831736
      Consensus CDS
      CCDS79849.1
      UniProtKB/TrEMBL
      F8WIU1
      Related
      ENSMUSP00000028800.6, ENSMUST00000028800.12
      Conserved Domains (1) summary
      pfam15006
      Location:31 → 176
      DUF4517; Domain of unknown function (DUF4517)

    2. NM_001361375.1 → NP_001348304.1  adipose-secreted signaling protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK006622, AL831736, BY706619, CX222938
      Conserved Domains (1) summary
      pfam15006
      Location:1 → 132
      DUF4517; Domain of unknown function (DUF4517)

    3. NM_026091.3 → NP_080367.1  adipose-secreted signaling protein isoform 2

      See identical proteins and their annotated locations for NP_080367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK003406, AL831736, BY706619
      Consensus CDS
      CCDS16756.1
      UniProtKB/Swiss-Prot
      Q9CVT3, Q9D1K7
      UniProtKB/TrEMBL
      H7BXB9
      Related
      ENSMUSP00000099477.4, ENSMUST00000103188.10
      Conserved Domains (1) summary
      pfam15006
      Location:28 → 173
      DUF4517; Domain of unknown function (DUF4517)

    RNA

    1. NR_154886.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831736
      Related
      ENSMUST00000184535.8

    2. NR_154887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831736

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130988235..131002001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251987.2 → XP_030107847.1  adipose-secreted signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q9CVT3, Q9D1K7
      UniProtKB/TrEMBL
      H7BXB9
      Conserved Domains (1) summary
      pfam15006
      Location:28 → 173
      DUF4517; Domain of unknown function (DUF4517)

    2. XM_011239745.3 → XP_011238047.1  adipose-secreted signaling protein isoform X1

      See identical proteins and their annotated locations for XP_011238047.1

      UniProtKB/Swiss-Prot
      Q9CVT3, Q9D1K7
      UniProtKB/TrEMBL
      H7BXB9
      Related
      ENSMUSP00000115000.2, ENSMUST00000133602.8
      Conserved Domains (1) summary
      pfam15006
      Location:28 → 173
      DUF4517; Domain of unknown function (DUF4517)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1K7.3 GenPept UniProtKB/Swiss-Prot:Q9D1K7

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