Hikeshi heat shock protein nuclear import factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hikeshiprovided by MGI
Official Full Name: heat shock protein nuclear import factorprovided by MGI
Primary source: MGI:MGI:96738
See related: Ensembl:ENSMUSG00000062797 AllianceGenome:MGI:96738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: l7Rn6; l(7)6Rn; 0610007P06Rik; 1110002N09Rik
Summary: Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Acts upstream of or within Golgi organization and lung development. Located in cytoplasm. Is expressed in several structures, including adrenal gland; heart; intestine; liver; and respiratory system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 6.9), CNS E14 (RPKM 6.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 50.4 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (89567893..89590446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (89918685..89941223, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
Title: Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
study identified downregulation of let-7 as an upstream mechanism for IGF1/IGF1R upregulation and activation of ERK1/2 and PI3K as a downstream mechanism mediating the IGF1 signaling cascade promoting spermatogenesis.
Title: Upstream and downstream mechanisms for the promoting effects of IGF-1 on differentiation of spermatogonia to primary spermatocytes.

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Phenotypes

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Associated conditions

Description	Tests
lethal, Chr 7, Rinchik 6 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW465254 (e-PCR)
- UniSTS:278080

BB155753 (e-PCR)
- UniSTS:185727

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein Hikeshi

Names: lethal gene on chromosome 7 Rinchik 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291286.2 → NP_001278215.1 protein Hikeshi isoform b

See identical proteins and their annotated locations for NP_001278215.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC161229, AC165077

UniProtKB/Swiss-Prot

Q9DD02

Conserved Domains (1) summary

pfam05603
Location:1 → 175

DUF775; Protein of unknown function (DUF775)
NM_001291287.2 → NP_001278216.1 protein Hikeshi isoform c

See identical proteins and their annotated locations for NP_001278216.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC161229, AC165077

Consensus CDS

CCDS80748.1

UniProtKB/Swiss-Prot

Q9DD02

Related

ENSMUSP00000102856.2, ENSMUST00000075010.12

Conserved Domains (1) summary

pfam05603
Location:1 → 156

DUF775; Protein of unknown function (DUF775)
NM_001291288.2 → NP_001278217.1 protein Hikeshi isoform d

See identical proteins and their annotated locations for NP_001278217.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

AC161229, AC165077

Consensus CDS

CCDS80747.1

UniProtKB/TrEMBL

A0A140LIK3

Conserved Domains (1) summary

pfam05603
Location:7 → 96

DUF775; Protein of unknown function (DUF775)
NM_001291289.2 → NP_001278218.1 protein Hikeshi isoform d

See identical proteins and their annotated locations for NP_001278218.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

AC161229, AC165077

Consensus CDS

CCDS80747.1

UniProtKB/TrEMBL

A0A140LIK3

Related

ENSMUST00000208357.2

Conserved Domains (1) summary

pfam05603
Location:7 → 96

DUF775; Protein of unknown function (DUF775)
NM_026304.4 → NP_080580.1 protein Hikeshi isoform a

See identical proteins and their annotated locations for NP_080580.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC161229, AC165077

Consensus CDS

CCDS21445.1

UniProtKB/Swiss-Prot

D3YUY2, Q30C40, Q9CZT7, Q9DD02

Related

ENSMUSP00000119806.2, ENSMUST00000153470.9

Conserved Domains (1) summary

pfam05603
Location:1 → 195

DUF775; Protein of unknown function (DUF775)

RNA

NR_111916.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) shares the first exon with variant 1 and then continues into the adjacent intron. This intronless is thought to be non-protein coding.

Source sequence(s)

AK133534, BY268898

Related

ENSMUST00000207695.2
NR_153788.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AC161229, AC165077, AI037128