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    KRS1 lysine--tRNA ligase KRS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KRS1
    Official Full Name
    lysine--tRNA ligase KRS1
    Primary source
    SGD:S000002444
    Locus tag
    YDR037W
    See related
    AllianceGenome:SGD:S000002444; FungiDB:YDR037W; VEuPathDB:YDR037W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GCD5
    Summary
    Enables lysine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in lysyl-tRNA aminoacylation. Located in cytoplasm. Used to study Charcot-Marie-Tooth disease recessive intermediate B; autosomal recessive nonsyndromic deafness 89; hypomyelinating leukoencephalopathy; and ophthalmoplegia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (525440..527215)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 3-deoxy-7-phosphoheptulonate synthase ARO3 Neighboring gene mitochondrial 37S ribosomal protein EHD3 Neighboring gene putative Na(+)-exporting P-type ATPase ENA5 Neighboring gene Na(+)-exporting P-type ATPase ENA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Do yeast aminoacyl-tRNA synthetases exist as soluble enzymes within the cytoplasm? Cirakoglu B, et al. Eur J Biochem, 1985 Jun 3. PMID 3888626
    2. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Hoepfner D, et al. Cell Host Microbe, 2012 Jun 14. PMID 22704625, Free PMC Article
    3. Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes. Sun C, et al. Neurol Genet, 2019 Apr. PMID 31192300, Free PMC Article
    4. The yeast lysyl-tRNA synthetase gene. Evidence for general amino acid control of its expression and domain structure of the encoded protein. Mirande M, et al. J Biol Chem, 1988 Dec 5. PMID 2903861
    5. The polyanion-binding domain of cytoplasmic Lys-tRNA synthetase from Saccharomyces cerevisiae is not essential for cell viability. Martinez R, et al. Eur J Biochem, 1992 Jul 1. PMID 1628641

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysine--tRNA ligase KRS1
    NP_010322.1
    • Lysyl-tRNA synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      525440..527215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180345.1 → NP_010322.1  TPA: lysine--tRNA ligase KRS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS25, P15180
      UniProtKB/TrEMBL
      A6ZY05, B3LGM8, B5VFU1, C8Z4V9
      Conserved Domains (1) summary
      PLN02502
      Location:24 → 579
      PLN02502; lysyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15180.2

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