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    folX dihydroneopterin triphosphate 2'-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946781, updated on 3-Dec-2024

    Summary

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    Official Symbol
    folX
    Official Full Name
    dihydroneopterin triphosphate 2'-epimerase
    Primary source
    ECOCYC:G7195
    Locus tag
    b2303
    See related
    ASAP:ABE-0007603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2297
    Summary
    Dihydroneopterin triphosphate 2'-epimerase has been known in Escherichia coli for some time. [More information is available at EcoCyc: G7195].
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    Genomic context

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    Sequence:
    NC_000913.3 (2421325..2421687)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase YfcF Neighboring gene disulfide bond oxidoreductase YfcG Neighboring gene epimerase family protein YfcH Neighboring gene recombination-promoting nuclease RpnB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic epimerization of D-erythro-dihydroneopterin triphosphate to L-threo-dihydroneopterin triphosphate. Heine MC, et al. Biochim Biophys Acta, 1975 Dec 5. PMID 1103974
    2. Pteridine excretion from cells as indicator of cell proliferation. Wachter H, et al. Naturwissenschaften, 1980 Dec. PMID 7015154
    3. Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli. Ahn C, et al. J Biol Chem, 1997 Jun 13. PMID 9182560
    4. Crystal structure of 7,8-dihydroneopterin triphosphate epimerase. Ploom T, et al. Structure, 1999 May. PMID 10378270
    5. (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin. Ikemoto K, et al. Biol Chem, 2002 Feb. PMID 11934271

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In E. coli, the folX deletion selectively eliminated tetrahydromonapterin production, which far exceeded folate production.
      Title: FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
    2. Site-directed mutagenesis study finds glutamate-73 important for substrate binding of dihydroneopterin aldolase (DHNA), but its role in catalysis is minor. Glu-21 and Lys-98 are important for both substrate binding and catalysis.
      Title: Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dihydroneopterin aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroneopterin triphosphate 2'-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydroneopterin triphosphate 2'-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroneopterin triphosphate 2'-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pteridine-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydroneopterin triphosphate 2'-epimerase
    NP_416806.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2421325..2421687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416806.1 dihydroneopterin triphosphate 2'-epimerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416806.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X3K9A0
      Conserved Domains (1) summary
      PRK11245
      Location:1 → 120
      folX; dihydroneopterin triphosphate 2'-epimerase
    Nucleotide Protein
    Heading Accession and Version

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