acpT holo-[acyl carrier protein] synthase 2 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: acpT
Official Full Name: holo-[acyl carrier protein] synthase 2
Primary source: ECOCYC:EG12221
Locus tag: b3475
See related: ASAP:ABE-0011351
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3459; yhhU
Summary: A nonsense mutation making a truncated YejM causes increased outer membrane permeability,TS growth, and reduced of lipid A synthesis; these phenotypes, and the lethality of a null mutation, are suppressible by a multicopy acpT clone (Hirvas, 1997; De Lay, 2008). [More information is available at EcoGene: EG12221]. The carrier protein substrates of AcpT have been identified in Escherichia coli O157:H7 strain EDL933 as Z4853 and Z4854, two proteins in O-island 138 which appears to contain genes for fatty-acid biosynthesis . [More information is available at EcoCyc: EG12221].
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NC_000913.3 Genomic Context describing neighboring genes

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Data provide genetic and biochemical evidence that AcpT modifies two carrier proteins encoded in O-island 138.
Title: A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates.

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Function	Evidence Code	Pubs
enables holo-[acyl-carrier-protein] synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables holo-[acyl-carrier-protein] synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables holo-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables holo-[acyl-carrier-protein] synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lysine biosynthetic process via aminoadipic acid	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_417932.1

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The following sections contain reference sequences that belong to a specific genome build. Explain