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    wzxE lipid IIIECA flippase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948294, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wzxE
    Official Full Name
    lipid IIIECA flippase
    Primary source
    ECOCYC:EG11486
    Locus tag
    b3792
    See related
    ASAP:ABE-0012386
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3784; wzx; yifJ
    Summary
    WzxE is a "flippase" responsible for movement of lipid III (Fuc4NAc-ManNAcA-GlcNAc-P-P-undecaprenol) across the membrane bilayer . [More information is available at EcoCyc: EG11486].
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    Genomic context

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    Sequence:
    NC_000913.3 (3976278..3977528)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene RffC Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase Neighboring gene enterobacterial common antigen polymerase Neighboring gene UDP-N-acetyl-D-mannosaminuronic acid transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. Alaimo C, et al. EMBO J, 2006 Mar 8. PMID 16498400, Free PMC Article
    2. The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat. Feldman MF, et al. J Biol Chem, 1999 Dec 3. PMID 10574995
    3. The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. Barr K, et al. J Bacteriol, 1999 Oct. PMID 10515954, Free PMC Article
    4. Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. Ramos-Morales F, et al. J Bacteriol, 2003 Sep. PMID 12923112, Free PMC Article
    5. Outer membrane vesicle production by Escherichia coli is independent of membrane instability. McBroom AJ, et al. J Bacteriol, 2006 Aug. PMID 16855227, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables intramembrane lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobacterial common antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipid IIIECA flippase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3976278..3977528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418239.1 lipid IIIECA flippase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418239.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1J7V7
      Conserved Domains (1) summary
      PRK15099
      Location:1 → 416
      PRK15099; lipid III flippase WzxE
    Nucleotide Protein
    Heading Accession and Version

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