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    CCA1 tRNA adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCA1
    Official Full Name
    tRNA adenylyltransferase
    Primary source
    SGD:S000000970
    Locus tag
    YER168C
    See related
    AllianceGenome:SGD:S000000970; FungiDB:YER168C; VEuPathDB:YER168C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TNT1
    Summary
    Enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; CCA tRNA nucleotidyltransferase activity; and CTP:tRNA cytidylyltransferase activity. Involved in tRNA 3'-terminal CCA addition. Located in mitochondrial matrix. Used to study sideroblastic anemia and sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCA1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (521029..522669, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene aminophospholipid-translocating P4-type ATPase DNF1 Neighboring gene Bck2p Neighboring gene Rph1p Neighboring gene adenylate kinase ADK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae. Peltz SW, et al. Mol Cell Biol, 1992 Dec. PMID 1448105, Free PMC Article
    2. Mechanisms leading to and the consequences of altering the normal distribution of ATP(CTP):tRNA nucleotidyltransferase in yeast. Wolfe CL, et al. J Biol Chem, 1996 Mar 1. PMID 8617732
    3. Interplay of heterogeneous transcriptional start sites and translational selection of AUGs dictate the production of mitochondrial and cytosolic/nuclear tRNA nucleotidyltransferase from the same gene in yeast. Wolfe CL, et al. J Biol Chem, 1994 May 6. PMID 8175766
    4. Characterization of a temperature-sensitive mutation that impairs the function of yeast tRNA nucleotidyltransferase. Shan X, et al. Yeast, 2008 Mar. PMID 18302315
    5. Recognition of tRNA by the enzyme ATP/CTP:tRNA nucleotidyltransferase. Interference by nucleotides modified with diethyl pyrocarbonate or hydrazine. Spacciapoli P, et al. J Biol Chem, 1989 Mar 5. PMID 2645279

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A single guanine-to-adenine transition in cca1-1 generates the temperature-sensitive phenotype.
      Title: Characterization of a temperature-sensitive mutation that impairs the function of yeast tRNA nucleotidyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCA tRNA nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCA tRNA nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CCACCA tRNA nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP:tRNA cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP:tRNA cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA 3'-terminal CCA addition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA adenylyltransferase
    NP_011095.1
    • ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      521029..522669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179058.1 → NP_011095.1  TPA: tRNA adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM76, P21269
      UniProtKB/TrEMBL
      A0A1L4A9Y3, A6ZRC4, B3LRS8, B5VHU6, C7GS42, C8Z7J1, G2WD54
      Conserved Domains (1) summary
      COG0617
      Location:37 → 532
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21269.1

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