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    Ankrd9 ankyrin repeat domain 9 [ Mus musculus (house mouse) ]

    Gene ID: 74251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd9provided by MGI
    Official Full Name
    ankyrin repeat domain 9provided by MGI
    Primary source
    MGI:MGI:1921501
    See related
    Ensembl:ENSMUSG00000037904 AllianceGenome:MGI:1921501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2500003O20Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intracellular copper ion homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ANKRD9 (ankyrin repeat domain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 50.8), small intestine adult (RPKM 40.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd9 in Genome Data Viewer
    Location:
    12 F1; 12 60.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110942854..110945516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110976420..110979082, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1157 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene ribosomal protein S19, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_33311 Neighboring gene STARR-positive B cell enhancer ABC_E10773 Neighboring gene STARR-positive B cell enhancer ABC_E7183 Neighboring gene predicted gene, 51959 Neighboring gene RIKEN cDNA 6030440G07 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular copper ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361916.1 → NP_001348845.1  ankyrin repeat domain-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      AC153152
      Consensus CDS
      CCDS26174.1
      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Related
      ENSMUSP00000119339.2, ENSMUST00000135131.2
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    2. NM_001361917.1 → NP_001348846.1  ankyrin repeat domain-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      AC153152
      Consensus CDS
      CCDS26174.1
      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Related
      ENSMUSP00000121279.2, ENSMUST00000140788.8
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    3. NM_175207.5 → NP_780416.2  ankyrin repeat domain-containing protein 9

      See identical proteins and their annotated locations for NP_780416.2

      Status: VALIDATED

      Source sequence(s)
      AK032641, AK051108
      Consensus CDS
      CCDS26174.1
      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Related
      ENSMUSP00000120816.2, ENSMUST00000128353.8
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110942854..110945516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516294.5 → XP_006516357.1  ankyrin repeat domain-containing protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006516357.1

      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    2. XM_030246958.2 → XP_030102818.1  ankyrin repeat domain-containing protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    3. XM_030246957.2 → XP_030102817.1  ankyrin repeat domain-containing protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q3TA09, Q8BH83, Q8BHR3
      UniProtKB/TrEMBL
      D3Z2N1
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH83.1 GenPept UniProtKB/Swiss-Prot:Q8BH83

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