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    Sfxn4 sideroflexin 4 [ Mus musculus (house mouse) ]

    Gene ID: 94281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfxn4provided by MGI
    Official Full Name
    sideroflexin 4provided by MGI
    Primary source
    MGI:MGI:2137680
    See related
    Ensembl:ENSMUSG00000063698 AllianceGenome:MGI:2137680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Located in mitochondrion. Is expressed in brain; metanephros; and testis. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 18. Orthologous to human SFXN4 (sideroflexin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 2.7), cerebellum adult (RPKM 2.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sfxn4 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60824747..60850222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60836309..60861533, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene microRNA 3084-2 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene STARR-positive B cell enhancer ABC_E11681 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965501-60965802 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965940-60966241 Neighboring gene peroxiredoxin 3 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Fleming MD, et al. Genes Dev, 2001 Mar 15. PMID 11274051, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107253

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362384.1 → NP_001349313.1  sideroflexin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102432, AC163019
      Conserved Domains (1) summary
      cl04275
      Location:1 → 217
      Mtc; Tricarboxylate carrier

    2. NM_001362385.1 → NP_001349314.1  sideroflexin-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102432, AC163019, AK148530
      Conserved Domains (1) summary
      cl04275
      Location:1 → 212
      Mtc; Tricarboxylate carrier

    3. NM_053198.4 → NP_444428.3  sideroflexin-4 isoform 1

      See identical proteins and their annotated locations for NP_444428.3

      Status: VALIDATED

      Source sequence(s)
      AC102432, AC163019
      Consensus CDS
      CCDS29943.1
      UniProtKB/Swiss-Prot
      E9QKN7, Q5FW99, Q925N1
      Related
      ENSMUSP00000118743.2, ENSMUST00000135808.8
      Conserved Domains (1) summary
      pfam03820
      Location:15 → 312
      Mtc; Tricarboxylate carrier

    RNA

    1. NR_189655.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102432, AC163019
      Related
      ENSMUST00000080806.10

    2. NR_189656.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102432, AC163019

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60824747..60850222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161735.1 → XP_036017628.1  sideroflexin-4 isoform X1

      Conserved Domains (1) summary
      cl04275
      Location:15 → 287
      Mtc; Tricarboxylate carrier

    2. XM_030251146.2 → XP_030107006.1  sideroflexin-4 isoform X2

      Conserved Domains (1) summary
      cl04275
      Location:1 → 217
      Mtc; Tricarboxylate carrier

    RNA

    1. XR_001782624.3 RNA Sequence

    2. XR_004940190.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925N1.2 GenPept UniProtKB/Swiss-Prot:Q925N1

    Gene LinkOut

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