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    RHOT1 ras homolog family member T1 [ Bos taurus (domestic cattle) ]

    Gene ID: 511257, updated on 1-Jan-2025

    Summary

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    Official Symbol
    RHOT1provided by VGNC
    Official Full Name
    ras homolog family member T1provided by VGNC
    Primary source
    VGNC:VGNC:33953
    See related
    BGD:BT12819; Ensembl:ENSBTAG00000010001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RHOT1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (17908913..17977507, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene chromosome 19 C17orf75 homolog Neighboring gene transfer RNA glutamine (anticodon UUG) Neighboring gene rhomboid like 3 Neighboring gene microRNA mir-2285cv-1 Neighboring gene ring finger protein 135 Neighboring gene ArfGAP with dual PH domains 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128572

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial Rho GTPase 1
    Names
    MIRO-1
    ras homolog gene family, member T1
    NP_001039547.1
    XP_005220053.2
    XP_005220054.2
    XP_005220055.2
    XP_010814067.2
    XP_015314026.2
    XP_024835695.1
    XP_024835698.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046082.1 → NP_001039547.1  mitochondrial Rho GTPase 1

      See identical proteins and their annotated locations for NP_001039547.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105456
      UniProtKB/Swiss-Prot
      Q2HJF8
      UniProtKB/TrEMBL
      A0A3Q1M400
      Related
      ENSBTAP00000035196.5, ENSBTAT00000035318.5
      Conserved Domains (4) summary
      cd01892
      Location:428 → 605
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17908913..17977507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005219997.3 → XP_005220054.2  mitochondrial Rho GTPase 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M400, A0A3Q1M503
      Related
      ENSBTAP00000068711.2, ENSBTAT00000085770.2
      Conserved Domains (4) summary
      cd01892
      Location:428 → 594
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    2. XM_005219996.4 → XP_005220053.2  mitochondrial Rho GTPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M400
      Conserved Domains (4) summary
      cd01892
      Location:428 → 594
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    3. XM_005219998.3 → XP_005220055.2  mitochondrial Rho GTPase 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M400, A0A3Q1MKH9
      Related
      ENSBTAP00000071386.1, ENSBTAT00000077284.2
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    4. XM_010815765.3 → XP_010814067.2  mitochondrial Rho GTPase 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M400, A0A3Q1MEL1
      Related
      ENSBTAP00000068937.1, ENSBTAT00000070355.2
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    5. XM_024979927.2 → XP_024835695.1  mitochondrial Rho GTPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M400
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    6. XM_015458540.3 → XP_015314026.2  mitochondrial Rho GTPase 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1M400
      Conserved Domains (4) summary
      cd01892
      Location:428 → 594
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    7. XM_024979930.2 → XP_024835698.1  mitochondrial Rho GTPase 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M400
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    RNA

    1. XR_009491515.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HJF8.1 GenPept UniProtKB/Swiss-Prot:Q2HJF8

    Gene LinkOut

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