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    PRKN parkin RBR E3 ubiquitin protein ligase [ Bos taurus (domestic cattle) ]

    Gene ID: 530858, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PRKNprovided by VGNC
    Official Full Name
    parkin RBR E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:33342
    See related
    BGD:BT15142; Ensembl:ENSBTAG00000018996
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PARK2
    Orthologs
    human mouse all
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    Genomic context

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    See PRKN in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (96957805..98192594, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene uncharacterized LOC132346164 Neighboring gene microRNA mir-2482 Neighboring gene parkin coregulated Neighboring gene cytochrome c oxidase subunit VIc-like Neighboring gene high mobility group protein B1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Characterization of parkin in bovine peripheral nerve. Hase A, et al. Brain Res, 2002 Mar 15. PMID 11879804
    2. Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein. Li RR, et al. Reprod Domest Anim, 2024 Jan. PMID 37917556
    3. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Kitada T, et al. Nature, 1998 Apr 9. PMID 9560156
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein.
      Title: Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase parkin
    Names
    Parkinson disease (autosomal recessive, juvenile) 2, parkin
    parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    NP_001185994.1
    XP_024852452.1
    XP_024852453.1
    XP_024852454.1
    XP_024852455.1
    XP_024852456.1
    XP_024852457.1
    XP_024852460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199065.1 → NP_001185994.1  E3 ubiquitin-protein ligase parkin

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000009
      UniProtKB/TrEMBL
      D3JW61, G3MY23
      Related
      ENSBTAP00000054449.2, ENSBTAT00000065043.3
      Conserved Domains (4) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:308 → 370
      IBR; In Between Ring fingers
      cd16627
      Location:231 → 289
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 134
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      96957805..98192594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996692.2 → XP_024852460.1  E3 ubiquitin-protein ligase parkin isoform X6

      UniProtKB/TrEMBL
      A0AAA9U024, G3N2Z7
      Related
      ENSBTAP00000056268.3, ENSBTAT00000063967.3
      Conserved Domains (5) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:308 → 370
      IBR; In Between Ring fingers
      pfam01485
      Location:408 → 448
      IBR; IBR domain, a half RING-finger domain
      cd16627
      Location:231 → 289
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 134
      UBQ; Ubiquitin homologues

    2. XM_024996689.2 → XP_024852457.1  E3 ubiquitin-protein ligase parkin isoform X5

      UniProtKB/TrEMBL
      A0AAA9U024
      Conserved Domains (5) summary
      cd01798
      Location:21 → 90
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:326 → 388
      IBR; In Between Ring fingers
      pfam01485
      Location:426 → 466
      IBR; IBR domain, a half RING-finger domain
      cd16627
      Location:249 → 307
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:31 → 152
      UBQ; Ubiquitin homologues

    3. XM_024996685.2 → XP_024852453.1  E3 ubiquitin-protein ligase parkin isoform X2

      UniProtKB/TrEMBL
      G3MY23
      Conserved Domains (3) summary
      cd01798
      Location:21 → 90
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:325 → 387
      IBR; In Between Ring fingers
      cd16627
      Location:248 → 306
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins

    4. XM_024996688.2 → XP_024852456.1  E3 ubiquitin-protein ligase parkin isoform X4

      UniProtKB/TrEMBL
      G3MY23
      Conserved Domains (4) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:308 → 370
      IBR; In Between Ring fingers
      cd16627
      Location:231 → 289
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 134
      UBQ; Ubiquitin homologues

    5. XM_024996686.2 → XP_024852454.1  E3 ubiquitin-protein ligase parkin isoform X3

      UniProtKB/TrEMBL
      D3JW61, G3MY23
      Conserved Domains (4) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:308 → 370
      IBR; In Between Ring fingers
      cd16627
      Location:231 → 289
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 134
      UBQ; Ubiquitin homologues

    6. XM_024996687.2 → XP_024852455.1  E3 ubiquitin-protein ligase parkin isoform X3

      UniProtKB/TrEMBL
      D3JW61, G3MY23
      Conserved Domains (4) summary
      cd01798
      Location:3 → 72
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:308 → 370
      IBR; In Between Ring fingers
      cd16627
      Location:231 → 289
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:13 → 134
      UBQ; Ubiquitin homologues

    7. XM_024996684.2 → XP_024852452.1  E3 ubiquitin-protein ligase parkin isoform X1

      UniProtKB/TrEMBL
      G3MY23
      Conserved Domains (4) summary
      cd01798
      Location:21 → 90
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:326 → 388
      IBR; In Between Ring fingers
      cd16627
      Location:249 → 307
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cl28408
      Location:31 → 152
      UBQ; Ubiquitin homologues
    Nucleotide Protein Strain
    Heading Accession and Version

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