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    Slc22a2 solute carrier family 22 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29503, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc22a2provided by RGD
    Official Full Name
    solute carrier family 22 member 2provided by RGD
    Primary source
    RGD:61936
    See related
    EnsemblRapid:ENSRNOG00000016625 AllianceGenome:RGD:61936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OCT2; OCT2r; rOCT2
    Summary
    Enables several functions, including monoamine transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including acetylcholine transport; histamine transport; and monoamine transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 601.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc22a2 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50668817..50711019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48121061..48163268, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48318025..48360219, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482693 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene solute carrier family 22 member 1 Neighboring gene uncharacterized LOC134484995 Neighboring gene protein LSM12 homolog pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 10 Neighboring gene uncharacterized LOC102553224

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylcholine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables amine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neurotransmitter transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables putrescine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables putrescine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyrimidine nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyrimidine nucleoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables quaternary ammonium group transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables quaternary ammonium group transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables spermidine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables steroid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables toxin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables toxin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetylcholine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in acetylcholine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetylcholine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epinephrine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in norepinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in organic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in putrescine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in putrescine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in putrescine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in quaternary ammonium group transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in quaternary ammonium group transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in serotonin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in serotonin uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermidine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thiamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thiamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thiamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier family 22 member 2
    Names
    organic cation transporter 2
    solute carrier family 22 (organic cation transporter), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031584.2NP_113772.1  solute carrier family 22 member 2

      See identical proteins and their annotated locations for NP_113772.1

      Status: PROVISIONAL

      Source sequence(s)
      D83044
      UniProtKB/Swiss-Prot
      P70485, P97558, Q9R0W2
      UniProtKB/TrEMBL
      A0A0G2JSP9, A6KJX5
      Related
      ENSRNOP00000023116.2, ENSRNOT00000023116.7
      Conserved Domains (2) summary
      cd06174
      Location:125492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50668817..50711019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)