Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2c23provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 23provided by RGD
Primary source: RGD:620370
See related: EnsemblRapid:ENSRNOG00000013291 AllianceGenome:RGD:620370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arachidonate 11,12-epoxygenase activity and arachidonate 14,15-epoxygenase activity. Involved in epoxygenase P450 pathway; icosanoid biosynthetic process; and response to testosterone. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 6227.8) and Liver (RPKM 2803.0) See more
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Genomic context

Location:: 1q54

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252838427..252863081, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242889218..242913869, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263778510..263803166, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2C11 and CYP2C23 epoxygenases were highly expressed in interlobar renal arteries and renal cortex, respectively, and were co-localized with eNOS in renal endothelial cells. These results demonstrate that H2O2 is involved in the EDH-type relaxant responses of renal arteries and that CYP 2C epoxygenases are physiologically relevant endothelial sources of vasodilator H2O2 in the kidney.
Title: CYP epoxygenase-derived H(2)O(2) is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries.
Epoxygenase activity of cultured astrocytes and neurons shows reduction in total epoxyeicosatrienoic acids and DiHETE production (to 80% and approximately 70% of vehicle respectively) in presence of amyloid beta.
Title: Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain.
docosahexaenoic acid-mediated vasodilatation is mediated through CYP epoxygenase metabolites by activation of vascular BK channels
Title: Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.
High dietary potassium enhances the inhibitory effect of arachidonic acid and 11,12-epoxyeicosatrienoic acid on ENaC by increasing cytochrome P450 epoxygenase activity and decreasing soluble epoxide hydrolase activity, respectively.
Title: High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.
Increased vascular tone brought about by downregulation of CYP2C23 and decreased levels of vasodilatory EETs may constitute important factors in androgen-induced hypertension.
Title: Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension.
low sodium intake downregulates the activity and expression of CYP2C23 and attenuates the inhibitory effect of arachidonic acid on sodium transport
Title: Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC.
These data suggest that TNF-alpha contributes to downregulation of Cyp2c23, blood pressure regulation, and renal injury in angiotensin high-salt hypertension.
Title: Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate 11,12-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2C23

Names: CYPIIC23; arachidonic acid epoxygenase

NP_114027.2

EC 1.14.14.1

XP_017445274.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.