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    NCK2 NCK adaptor protein 2 [ Canis lupus dingo (dingo) ]

    Gene ID: 112669668, updated on 15-Mar-2024

    Summary

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    Gene symbol
    NCK2
    Gene description
    NCK adaptor protein 2
    See related
    Ensembl:ENSCAFG00020010438
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus dingo (sub-species: dingo)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NCK2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    102 current ASM325472v2 (GCF_003254725.2) 10 NC_064252.1 (38422491..38572203, complement)
    101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 10 Unlocalized Scaffold NW_023365144.1 (39316261..39466308, complement)

    Chromosome 10 - NC_064252.1Genomic Context describing neighboring genes Neighboring gene ECRG4 augurin precursor Neighboring gene uncharacterized LOC112675112 Neighboring gene uncharacterized LOC125755939 Neighboring gene uncharacterized LOC112669681 Neighboring gene uncharacterized LOC112669683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM325472v2

    Genomic

    1. NC_064252.1 Reference ASM325472v2

      Range
      38422491..38572203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025462963.3 → XP_025318748.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_025462951.3 → XP_025318736.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_025462980.3 → XP_025318765.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_025462945.3 → XP_025318730.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Related
      ENSCAFP00020012957.1
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
    Nucleotide Protein
    Heading Accession and Version

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