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    edl ETS-domain lacking [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    edlprovided by FlyBase
    Official Full Name
    ETS-domain lackingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023214
    Locus tag
    Dmel_CG15085
    See related
    AllianceGenome:FB:FBgn0023214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02077276.2; anon-WO02077276.3; CG15085; Dmel\CG15085; Edl; EDL; edl/mae; l(2)k06602; mae; Mae; MAE
    Summary
    Enables DNA-binding transcription factor binding activity and DNA-binding transcription repressor activity. Involved in several processes, including negative regulation of DNA-templated transcription; photoreceptor cell development; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including endoderm anlage; gut section; head epidermis primordium; neurogenic region; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See edl in Genome Data Viewer
    Location:
    55E6-55E6; 2-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18667527..18673536, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14555032..14561041, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GDI interacting protein 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping candidate genes for Drosophila melanogaster resistance to the parasitoid wasp Leptopilina boulardi. Hita M, et al. Genet Res, 2006 Oct. PMID 17125583
    2. Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Qiao F, et al. Cell, 2004 Jul 23. PMID 15260987
    3. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song H, et al. Genes Dev, 2005 Aug 1. PMID 16027171, Free PMC Article
    4. Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse. Kantorovitz MR, et al. Dev Cell, 2009 Oct. PMID 19853570, Free PMC Article
    5. Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. Qiao F, et al. EMBO J, 2006 Jan 11. PMID 16362034, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. prior to Ras activation, the Mae/Yan interaction blocks premature nuclear export of Yan monomers
      Title: Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response.
    2. Efficient phosphorylation and consequent activation of Pnt-P2 requires a three-dimensional docking surface on its SAM domain for the MAP kinase but Mae binding to Pnt-P2 occludes this docking surface.
      Title: Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site.
    3. A dual positive and negative regulator of RTK-mediated signaling.
      Title: MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN.
    4. Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases.
      Title: Derepression by depolymerization; structural insights into the regulation of Yan by Mae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear export IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS-domain lacking
    Names
    CG15085-PA
    Ets domain lacking
    edl-PA
    modulator of the activity of Ets

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18667527..18673536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079062.3 → NP_523786.2  ETS-domain lacking [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523786.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K119
      Related
      FBpp0085834
      Conserved Domains (1) summary
      cd08536
      Location:103 → 170
      SAM_PNT-Mae; Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K119 Q7K119

    Gene LinkOut

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