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    kbrl-1 NF-kappa-B inhibitor-interacting Ras-like protein [ Caenorhabditis elegans ]

    Gene ID: 172487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kbrl-1
    Official Full Name
    NF-kappa-B inhibitor-interacting Ras-like protein
    Primary source
    WormBase:WBGene00009919
    Locus tag
    CELE_F52A8.6
    See related
    AllianceGenome:WB:WBGene00009919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Is expressed in head. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1) and NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kbrl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7347222..7350386)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Globin domain-containing protein Neighboring gene Glycine cleavage system H protein Neighboring gene Innexin-14 Neighboring gene Expressed conserved protein Neighboring gene SCAVenger receptor (CD36 family) related Neighboring gene Olfactomedin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein
    NP_001040668.1
    • Confirmed by transcript evidence
    NP_001333545.1
    • Partially confirmed by transcript evidence
    NP_001333546.1
    • Partially confirmed by transcript evidence
    NP_492076.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7347222..7350386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059675.7 → NP_492076.1  NF-kappa-B inhibitor-interacting Ras-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19143
      Conserved Domains (2) summary
      TIGR00231
      Location:179 → 328
      small_GTP; small GTP-binding protein domain
      cl21455
      Location:183 → 322
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001346621.4 → NP_001333545.1  NF-kappa-B inhibitor-interacting Ras-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCM1

    3. NM_001346622.3 → NP_001333546.1  NF-kappa-B inhibitor-interacting Ras-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCL3

    4. NM_001047203.4 → NP_001040668.1  NF-kappa-B inhibitor-interacting Ras-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19143, Q1NZ24, Q20640, Q95QF4
      Conserved Domains (2) summary
      TIGR00231
      Location:14 → 163
      small_GTP; small GTP-binding protein domain
      cl21455
      Location:18 → 157
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_144481.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19143.4

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