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    rcsC histidine kinase RcsC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948993, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rcsC
    Official Full Name
    histidine kinase RcsC
    Primary source
    ECOCYC:EG10822
    Locus tag
    b2218
    See related
    ASAP:ABE-0007336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2211
    Summary
    RcsC belongs to the phophorelay system RcsC/RcsD/RcsB , and is involved in the regulation of the synthesis of colanic acid capsule and motility . [More information is available at EcoCyc: EG10822].
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    Genomic context

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    Sequence:
    NC_000913.3 (2317027..2319876, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RcsD phosphotransferase Neighboring gene DNA-binding transcriptional activator RcsB Neighboring gene sensor histidine kinase AtoS Neighboring gene DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit alpha Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Complex Rcs Regulatory Cascade. Wall E, et al. Annu Rev Microbiol, 2018 Sep 8. PMID 29897834
    2. Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12. Clarke DJ, et al. J Bacteriol, 2002 Feb. PMID 11807084, Free PMC Article
    3. Comparative functional analysis of the RcsC sensor kinase from different Enterobacteriaceae. Huang YH, et al. FEMS Microbiol Lett, 2009 Apr. PMID 19260968
    4. NMR assignment of 1H, 13C and 15N resonances of the truncated Escherichia coli RcsC (700-949), including the phosphoreceiver domain. Rogov VV, et al. J Biomol NMR, 2007 Jun. PMID 17036162
    5. TerF, the sixth identified replication arrest site in Escherichia coli, is located within the rcsC gene. Sharma B, et al. J Bacteriol, 1992 Dec. PMID 1447156, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RcsF also interacts with the periplasmic domain of the innermembrane-localized histidine kinase RcsC.
      Title: Role of the inner-membrane histidine kinase RcsC and outer-membrane lipoprotein RcsF in the activation of the Rcs phosphorelay signal transduction system in Escherichia coli.
    2. a number of signals that lead to activation of the phosphorelay require both RcsF and RcsC
      Title: Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli.
    3. Results describe the solution structure of the RcsC C terminus, possessing a phosphoreceiver domain (RcsC-PR) and a region previously described as a long linker between the histidine kinase domain of RcsC (RcsC-HK) and the RcsC-PR.
      Title: A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains.
    4. RcsB and RcsC inversely regulated the timing of flagellar biogenesis
      Title: Acetyl phosphate-sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histidine kinase RcsC
    NP_416722.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2317027..2319876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416722.2 histidine kinase RcsC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416722.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895NUG4
      Conserved Domains (1) summary
      PRK10841
      Location:24 → 947
      PRK10841; two-component system sensor histidine kinase RcsC
    Nucleotide Protein
    Heading Accession and Version

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