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    Maea macrophage erythroblast attacher, E3 ubiquitin ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maeaprovided by RGD
    Official Full Name
    macrophage erythroblast attacher, E3 ubiquitin ligaseprovided by RGD
    Primary source
    RGD:1309877
    See related
    EnsemblRapid:ENSRNOG00000005397 AllianceGenome:RGD:1309877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in cell adhesion; negative regulation of myeloid cell apoptotic process; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cytoskeleton organization and enucleate erythrocyte development. Predicted to be located in cytoskeleton; nuclear lumen; and plasma membrane. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 333.0), Heart (RPKM 290.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maea in Genome Data Viewer
    Location:
    14q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81581784..81615246, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77357261..77390683, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82664248..82697673, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NK1 homeobox 1 Neighboring gene UV-stimulated scaffold protein A Neighboring gene uncharacterized LOC134481860 Neighboring gene uncharacterized LOC134481861 Neighboring gene C-terminal binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. Soni S, et al. J Biol Chem, 2006 Jul 21. PMID 16707498
    2. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. Bala S, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16510120
    3. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. Hanspal M, et al. Blood, 1998 Oct 15. PMID 9763581
    4. Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. Francis O, et al. PLoS One, 2013. PMID 24143168, Free PMC Article
    5. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Kobayashi N, et al. Gene, 2007 Jul 15. PMID 17467196

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93683

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in enucleate erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enucleate erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actomyosin contractile ring IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actomyosin contractile ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein transferase MAEA
    NP_001008320.2
    XP_038947726.1
    XP_038947727.1
    XP_063129083.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008319.2 → NP_001008320.2  E3 ubiquitin-protein transferase MAEA

      See identical proteins and their annotated locations for NP_001008320.2

      Status: VALIDATED

      Source sequence(s)
      BC085770, CV109439
      UniProtKB/Swiss-Prot
      Q5RKJ1
      UniProtKB/TrEMBL
      A0A8L2Q2K9, A6IK66
      Related
      ENSRNOP00000007181.6, ENSRNOT00000007181.7
      Conserved Domains (3) summary
      smart00667
      Location:120 → 153
      LisH; Lissencephaly type-1-like homology motif
      cd16659
      Location:336 → 383
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
      pfam10607
      Location:160 → 301
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81581784..81615246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273013.1 → XP_063129083.1  E3 ubiquitin-protein transferase MAEA isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2K9

    2. XM_039091799.2 → XP_038947727.1  E3 ubiquitin-protein transferase MAEA isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q2K9
      Conserved Domains (3) summary
      smart00667
      Location:72 → 105
      LisH; Lissencephaly type-1-like homology motif
      cd16659
      Location:288 → 335
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
      pfam10607
      Location:112 → 253
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    3. XM_039091798.2 → XP_038947726.1  E3 ubiquitin-protein transferase MAEA isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q2K9
      Conserved Domains (3) summary
      smart00667
      Location:72 → 105
      LisH; Lissencephaly type-1-like homology motif
      cd16659
      Location:288 → 335
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
      pfam10607
      Location:112 → 253
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKJ1.2 GenPept UniProtKB/Swiss-Prot:Q5RKJ1

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