Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r14aprovided by MGI
Official Full Name: protein phosphatase 1, regulatory inhibitor subunit 14Aprovided by MGI
Primary source: MGI:MGI:1931139
See related: Ensembl:ENSMUSG00000037166 AllianceGenome:MGI:1931139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpi17; CPI-17; 1110001M11Rik
Summary: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; embryo endoderm; gut; nervous system; and respiratory system. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 168.4), lung adult (RPKM 163.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28988732..28992817)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (29289320..29293390)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension
Title: CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice.
These data provide a novel mechanism of the transcriptional control of CPI-17 in vascular smooth muscle cells under inflammatory conditions. Mechanistically, 2 GC boxes were identified as TNF response element in the CPI-17 promoter and KLF4 was upregulated by TNF, competed with Sp1 for the binding to the GC boxes in the CPI-17 promoter, and repressed CPI-17 transcription through histone deacetylase.
Title: Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality.
CPI-17 phosphorylation at T38 is essential for the maintenance of physiological blood pressure.
Title: The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice.
Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy.
Title: Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).
Title: GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.
a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle.
Title: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.
Organ-specific mechanisms involving MYPT1, M-RIP, and CPI-17 are critical to regulating basal LC20 phosphorylation in gastrointestinal smooth muscles.
Title: Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles.
calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals
Title: Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.
CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types.
Title: Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 14A

Names: 17 kDa PKC-potentiated inhibitory protein of PP1; protein kinase C-potentiated inhibitor protein of 17 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418823.1 → NP_001405752.1 protein phosphatase 1 regulatory subunit 14A isoform 2

Status: VALIDATED

Source sequence(s)

AC166079
NM_001418824.1 → NP_001405753.1 protein phosphatase 1 regulatory subunit 14A isoform 3

Status: VALIDATED

Source sequence(s)

AC166079

UniProtKB/TrEMBL

A0A140LI58

Related

ENSMUSP00000146684.2, ENSMUST00000207714.2
NM_001418825.1 → NP_001405754.1 protein phosphatase 1 regulatory subunit 14A isoform 4

Status: VALIDATED

Source sequence(s)

AC166079
NM_026731.4 → NP_081007.2 protein phosphatase 1 regulatory subunit 14A isoform 1

See identical proteins and their annotated locations for NP_081007.2

Status: VALIDATED

Source sequence(s)

AC166079

Consensus CDS

CCDS21070.1

UniProtKB/Swiss-Prot

Q91VC7, Q99MB9

Related

ENSMUSP00000035642.5, ENSMUST00000048187.6

Conserved Domains (1) summary

pfam05361
Location:1 → 134

PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor