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    serpini1.S serpin family I member 1 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444669, updated on 4-Jan-2025

    Summary

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    Official Symbol
    serpini1.S
    Official Full Name
    serpin family I member 1 S homeolog
    Primary source
    Xenbase:XB-GENE-948446
    Locus tag
    XELAEV_18029722mg
    See related
    EnsemblRapid:ENSXLAG00005007800 AllianceGenome:Xenbase:XB-GENE-948446
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    serpini1; neuroserpin
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See serpini1.S in Genome Data Viewer
    Location:
    chromosome: 5S
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (99861970..99908279, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (93518273..93564655, complement)

    Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108717578 Neighboring gene uncharacterized LOC121394081 Neighboring gene programmed cell death 10 S homeolog Neighboring gene WD repeat domain 49 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC84260

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin family I member 1 S homeolog
    Names
    serpin peptidase inhibitor, clade I (neuroserpin), member 1 S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092771.1 → NP_001086240.1  serpin family I member 1 S homeolog precursor

      See identical proteins and their annotated locations for NP_001086240.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074366
      UniProtKB/TrEMBL
      A0A974HHX2, Q2MDE1, Q6GLT7
      Related
      ENSXLAP00005022302.1, ENSXLAT00005022994.1
      Conserved Domains (1) summary
      cd02048
      Location:23 → 394
      serpinI1_NSP; serpin family I member 1, neuroserpin

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      99861970..99908279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018264432.2 → XP_018119921.1  serpin family I member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974HHX2, Q2MDE1, Q6GLT7
      Related
      ENSXLAP00005022287.1, ENSXLAT00005022978.1
      Conserved Domains (1) summary
      cd02048
      Location:23 → 394
      serpinI1_NSP; serpin family I member 1, neuroserpin

    2. XM_041564016.1 → XP_041419950.1  serpin family I member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974HHX2, Q2MDE1, Q6GLT7
      Related
      ENSXLAP00005022307.1, ENSXLAT00005022999.1
      Conserved Domains (1) summary
      cd02048
      Location:23 → 394
      serpinI1_NSP; serpin family I member 1, neuroserpin
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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