dnajc27.S DnaJ heat shock protein family (Hsp40) member C27 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dnajc27.S
Official Full Name: DnaJ heat shock protein family (Hsp40) member C27 S homeolog
Primary source: Xenbase:XB-GENE-490424
Locus tag: XELAEV_18030228mg
See related: EnsemblRapid:ENSXLAG00005005354 AllianceGenome:Xenbase:XB-GENE-490424
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rbj; rap1; rbj1; rbj2; rabjs; rjb-b; dnajc27-a; dnajc27-b
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in nucleus. Orthologous to human DNAJC27 (DnaJ heat shock protein family (Hsp40) member C27). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 5S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (139353499..139369889, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (132684913..132701691, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To understand the molecular basis behind interactions of two DnaJ domains and the function of the extra DnaJ domain, the Xenopus laevis Rbj (xRbj) protein was expressed in Escherichia coli and its crystal structure has been determined to a resolution of 2.7 A
Title: Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 27-B

Names: DnaJ (Hsp40) homolog, subfamily C, member 27; RBJ protein 2; Rab and DnaJ domain-containing protein B; rab and DnaJ domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095422.1 → NP_001088891.1 dnaJ homolog subfamily C member 27-B

Status: PROVISIONAL

Source sequence(s)

BC088700

UniProtKB/Swiss-Prot

Q5M7D1, Q6IML2

UniProtKB/TrEMBL

A0A974HIH2, A0A974HKY6

Related

ENSXLAP00005015785.1, ENSXLAT00005016073.1

Conserved Domains (3) summary

cd06257
Location:220 → 267

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

cd04119
Location:17 → 187

RJL; Rab GTPase family J-like (RabJ-like)

smart00175
Location:17 → 180

RAB; Rab subfamily of small GTPases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

139353499..139369889 complement

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GenBank, FASTA, Sequence Viewer (Graphics)