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    ddit4.S DNA damage inducible transcript 4 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379481, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ddit4.S
    Official Full Name
    DNA damage inducible transcript 4 S homeolog
    Primary source
    Xenbase:XB-GENE-944281
    Locus tag
    XELAEV_18037099mg
    See related
    EnsemblRapid:ENSXLAG00005025944 AllianceGenome:Xenbase:XB-GENE-944281
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ddit4; redd1; enpr02
    Summary
    Predicted to act upstream of or within apoptotic process and negative regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in cardiovascular system; ectoderm; nervous system; sensory system; and visual system. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ddit4.S in Genome Data Viewer
    Location:
    chromosome: 7S
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (29996722..29999652, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (28483671..28486601, complement)

    Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake 1 S homeolog Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 S homeolog Neighboring gene uncharacterized LOC121396276 Neighboring gene anaphase promoting complex subunit 16 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Ellisen LW, et al. Mol Cell, 2002 Nov. PMID 12453409
    2. An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N, et al. Mech Dev, 2005 Mar. PMID 15763213
    3. Axeldb: a Xenopus laevis database focusing on gene expression. Pollet N, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592204, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC64453

    Gene Ontology Provided by Xenbase

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA damage-inducible transcript 4 protein
    Names
    REDD-1
    protein regulated in development and DNA damage response 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086322.1 → NP_001079791.1  DNA damage-inducible transcript 4 protein

      See identical proteins and their annotated locations for NP_001079791.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054246
      UniProtKB/Swiss-Prot
      Q7SYV9
      UniProtKB/TrEMBL
      A0A974CBM2
      Related
      ENSXLAP00005077110.1, ENSXLAT00005078701.1
      Conserved Domains (1) summary
      pfam07809
      Location:94 → 210
      RTP801_C; RTP801 C-terminal region

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      29996722..29999652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SYV9.1 GenPept UniProtKB/Swiss-Prot:Q7SYV9

    Gene LinkOut

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