F32D8.7 BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F32D8.7
Official Full Name: BPTI/Kunitz inhibitor domain-containing protein
Primary source: WormBase:WBGene00009331
Locus tag: CELE_F32D8.7
See related: AllianceGenome:WB:WBGene00009331
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F32D8.7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (10898435..10900700)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32D8.7 (e-PCR)
- UniSTS:314195

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	HEP more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BPTI/Kunitz inhibitor domain-containing protein

NP_001122937.1

Confirmed by transcript evidence

NP_505779.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10898435..10900700

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129465.4 → NP_001122937.1 BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122937.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JYT7

Conserved Domains (2) summary

pfam03276
Location:110 → 176

Gag_spuma; Spumavirus gag protein

cl00101
Location:176 → 217

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
NM_073378.8 → NP_505779.1 BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505779.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19961

Conserved Domains (2) summary

pfam03276
Location:110 → 174

Gag_spuma; Spumavirus gag protein

cl00101
Location:174 → 215

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.