Antxr1 anthrax toxin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Antxr1provided by MGI
Official Full Name: anthrax toxin receptor 1provided by MGI
Primary source: MGI:MGI:1916788
See related: Ensembl:ENSMUSG00000033420 AllianceGenome:MGI:1916788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tem8; Antrx1; 2310008J16Rik; 2810405N18Rik
Summary: Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Acts upstream of or within blood vessel development; negative regulation of extracellular matrix assembly; and positive regulation of metallopeptidase activity. Predicted to be located in external side of plasma membrane; filopodium membrane; and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; chondrocranium; costal cartilage; immune system; and liver. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 23.9), bladder adult (RPKM 13.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.94 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87110835..87312757, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87133853..87335809, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted silencing of TEM8 suppresses nonsmall cell lung cancer tumor growth via the ERK/Bcl2 signaling pathway.
Title: Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway.
Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis.
Title: Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis.
ANTXR1 has a role in the regulation of RANKL-induced osteoclast differentiation and function
Title: Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function.
Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.
Title: Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.
An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease.
Title: Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia.
Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation.
Title: Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.
Anthrax toxin receptors in mouse and human macrophages were silenced using targeted siRNAs or blocked with specific antibody prior to challenge with anthrax lethal toxin.
Title: Targeted silencing of anthrax toxin receptors protects against anthrax toxins.
These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role.
Title: The receptors that mediate the direct lethality of anthrax toxin.
Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 plays only a minor role.
Title: Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.
Host-derived TEM8 promotes the growth of certain tumors.
Title: Host-derived tumor endothelial marker 8 promotes the growth of melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235487

NoName (e-PCR)
- UniSTS:235488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: anthrax toxin receptor 1

Names: tumor endothelial marker 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054041.2 → NP_473382.1 anthrax toxin receptor 1 precursor

See identical proteins and their annotated locations for NP_473382.1

Status: VALIDATED

Source sequence(s)

BB649806, BC094544

Consensus CDS

CCDS20318.1

UniProtKB/Swiss-Prot

Q505H2, Q9CZ52

UniProtKB/TrEMBL

A0A0N4SV16

Related

ENSMUSP00000045634.10, ENSMUST00000042025.12

Conserved Domains (3) summary

cd01474
Location:37 → 221

vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...

pfam05586
Location:394 → 486

Ant_C; Anthrax receptor C-terminus region

pfam05587
Location:223 → 317

Anth_Ig; Anthrax receptor extracellular domain