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    Necab1 N-terminal EF-hand calcium binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 69352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Necab1provided by MGI
    Official Full Name
    N-terminal EF-hand calcium binding protein 1provided by MGI
    Primary source
    MGI:MGI:1916602
    See related
    Ensembl:ENSMUSG00000040536 AllianceGenome:MGI:1916602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Efcbp1; STIP-1; 1700003H21Rik
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in early conceptus. Orthologous to human NECAB1 (N-terminal EF-hand calcium binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.2), cortex adult (RPKM 9.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Necab1 in Genome Data Viewer
    Location:
    4 A2; 4 6.45 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14952245..15149804, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14952245..15149804, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene OTU domain containing 6B Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene predicted gene 11837 Neighboring gene STARR-seq mESC enhancer starr_09640 Neighboring gene STARR-seq mESC enhancer starr_09641 Neighboring gene predicted gene 11844 Neighboring gene predicted gene, 36801 Neighboring gene STARR-seq mESC enhancer starr_09642 Neighboring gene STARR-seq mESC enhancer starr_09643 Neighboring gene STARR-seq mESC enhancer starr_09646 Neighboring gene STARR-seq mESC enhancer starr_09648 Neighboring gene STARR-positive B cell enhancer ABC_E6154 Neighboring gene predicted gene, 51436 Neighboring gene transmembrane protein 64 Neighboring gene STARR-seq mESC enhancer starr_09650 Neighboring gene predicted gene, 29883 Neighboring gene predicted gene, 29829

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cholinergic modulation of Up-Down states in the mouse medial entorhinal cortex in vitro. Hay YA, et al. Eur J Neurosci, 2021 Mar. PMID 33131134
    2. Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus. Zimmermann B, et al. Brain Res, 2013 Aug 28. PMID 23850650
    3. Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells. Udagawa H, et al. Sci Rep, 2023 Oct 20. PMID 37863964, Free PMC Article
    4. Thalamus mediates neocortical Down state transition via GABA(B)-receptor-targeting interneurons. Hay YA, et al. Neuron, 2021 Sep 1. PMID 34314698
    5. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Sugita S, et al. Neuroscience, 2002. PMID 12044471

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic beta-cells.
      Title: Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells.
    2. The genes for the three Necab's, including Necab-1, were expressed in specific, non-overlapping areas of the hippocampus.
      Title: Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of amyloid precursor protein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-terminal EF-hand calcium-binding protein 1
    Names
    EF-hand calcium-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178617.4 → NP_848732.3  N-terminal EF-hand calcium-binding protein 1

      See identical proteins and their annotated locations for NP_848732.3

      Status: VALIDATED

      Source sequence(s)
      BC067055
      Consensus CDS
      CCDS17982.1
      UniProtKB/Swiss-Prot
      Q80W91, Q8BG18
      Related
      ENSMUSP00000038165.8, ENSMUST00000041606.14
      Conserved Domains (3) summary
      pfam03992
      Location:254 → 325
      ABM; Antibiotic biosynthesis monooxygenase
      pfam13499
      Location:33 → 89
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:31 → 87
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      14952245..15149804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538234.1 → XP_006538297.1  N-terminal EF-hand calcium-binding protein 1 isoform X1

      Conserved Domains (4) summary
      cd00051
      Location:55 → 111
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15898
      Location:57 → 83
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:57 → 168
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      pfam03992
      Location:278 → 347
      ABM; Antibiotic biosynthesis monooxygenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG18.1 GenPept UniProtKB/Swiss-Prot:Q8BG18

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