P4ha3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P4ha3provided by MGI
Official Full Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide IIIprovided by MGI
Primary source: MGI:MGI:2444049
See related: Ensembl:ENSMUSG00000051048 AllianceGenome:MGI:2444049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D930031A02Rik
Summary: Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; ear; respiratory system; and skeleton. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 12.1), CNS E14 (RPKM 3.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.34 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99934637..99968908)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100285489..100319701)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties
Title: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prolyl 4-hydroxylase subunit alpha-3

Names: 4-PH alpha-3; collagen prolyl 4-hydroxylase alpha 3; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3

NP_796135.3

EC 1.14.11.2

XP_006508007.1

EC 1.14.11.2

XP_036009059.1

EC 1.14.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177161.4 → NP_796135.3 prolyl 4-hydroxylase subunit alpha-3 precursor

Status: VALIDATED

Source sequence(s)

AC122269

Consensus CDS

CCDS21496.1

UniProtKB/Swiss-Prot

Q640R2, Q6W3F0, Q8C3A6

UniProtKB/TrEMBL

H7BX23

Related

ENSMUSP00000055297.6, ENSMUST00000057023.12

Conserved Domains (2) summary

smart00702
Location:354 → 526

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam08336
Location:31 → 157

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

99934637..99968908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507944.5 → XP_006508007.1 prolyl 4-hydroxylase subunit alpha-3 isoform X1

UniProtKB/Swiss-Prot

Q640R2, Q6W3F0, Q8C3A6

Conserved Domains (2) summary

smart00702
Location:363 → 535

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam08336
Location:31 → 157

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
XM_036153166.1 → XP_036009059.1 prolyl 4-hydroxylase subunit alpha-3 isoform X2

Conserved Domains (1) summary

pfam08336
Location:32 → 106

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region