Sart3 squamous cell carcinoma antigen recognized by T cells 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sart3provided by MGI
Official Full Name: squamous cell carcinoma antigen recognized by T cells 3provided by MGI
Primary source: MGI:MGI:1858230
See related: Ensembl:ENSMUSG00000018974 AllianceGenome:MGI:1858230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0156
Summary: Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Acts upstream of or within cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Located in Cajal body. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.4), CNS E14 (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.55 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (113880505..113910461, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113742444..113772400, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135503 (e-PCR)
- UniSTS:164882

Sart3 (e-PCR), detects polymorphism
- UniSTS:479256

AU045857 (e-PCR)
- UniSTS:159423

SART3 (e-PCR)
- UniSTS:258303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables U4 snRNA binding	IEA Inferred from Electronic Annotation more info
enables U4 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables U6atac snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6atac snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal tri-snRNP complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal tri-snRNP complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ASAP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of U4/U6 snRNP	ISO Inferred from Sequence Orthology more info
part_of U4/U6 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of U6atac snRNP	ISO Inferred from Sequence Orthology more info
part_of U6atac snRNP	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: squamous cell carcinoma antigen recognized by T-cells 3

Names: SART-3; mSART-3; tumor-rejection antigen SART3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356621.1 → NP_001343550.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC132939

Conserved Domains (4) summary

cd12391
Location:723 → 796

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:817 → 897

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam16605
Location:895 → 953

LSM_int_assoc; LSM-interacting associated unstructured

cl26993
Location:101 → 479

Suf; Suppressor of forked protein (Suf)
NM_001356623.1 → NP_001343552.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC132939

Conserved Domains (3) summary

cd12391
Location:316 → 389

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:410 → 490

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cl25617
Location:488 → 546

LSM_int_assoc; LSM-interacting associated unstructured
NM_016926.2 → NP_058622.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

See identical proteins and their annotated locations for NP_058622.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC132939, AK086398

Consensus CDS

CCDS19552.1

UniProtKB/Swiss-Prot

Q6ZQI2, Q8BPK9, Q8C3B7, Q8CFU9, Q9JLI8

Related

ENSMUSP00000019118.4, ENSMUST00000019118.8

Conserved Domains (7) summary

COG0724
Location:641 → 858

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

COG5107
Location:101 → 461

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:705 → 778

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:799 → 879

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:944 → 961

Lsm_interact; Lsm interaction motif

pfam08424
Location:334 → 487

NRDE-2; NRDE-2, necessary for RNA interference

pfam16605
Location:877 → 935

LSM_int_assoc; LSM-interacting associated unstructured

RNA

NR_151532.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) has several differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC132939

Related

ENSMUST00000197041.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

113880505..113910461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254699.1 → XP_030110559.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

Conserved Domains (5) summary

COG5107
Location:1 → 323

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:567 → 640

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:661 → 741

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:806 → 823

Lsm_interact; Lsm interaction motif

pfam16605
Location:739 → 797

LSM_int_assoc; LSM-interacting associated unstructured
XM_006530406.1 → XP_006530469.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

Conserved Domains (5) summary

COG5107
Location:1 → 341

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:585 → 658

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:679 → 759

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:824 → 841

Lsm_interact; Lsm interaction motif

pfam16605
Location:757 → 815

LSM_int_assoc; LSM-interacting associated unstructured