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    Apom apolipoprotein M [ Mus musculus (house mouse) ]

    Gene ID: 55938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Apomprovided by MGI
    Official Full Name
    apolipoprotein Mprovided by MGI
    Primary source
    MGI:MGI:1930124
    See related
    Ensembl:ENSMUSG00000024391 AllianceGenome:MGI:1930124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3a; NG20; 1190010O19Rik
    Summary
    Enables antioxidant activity. Involved in several processes, including cholesterol efflux; high-density lipoprotein particle clearance; and plasma lipoprotein particle organization. Acts upstream of or within lipoprotein metabolic process and reverse cholesterol transport. Located in extracellular region. Part of discoidal high-density lipoprotein particle. Is expressed in several structures, including gut; liver; male reproductive gland or organ; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 336.8), liver E18 (RPKM 311.5) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Apom in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35347973..35350777, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35128997..35131801, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene predicted gene 20522 Neighboring gene DNA segment, Chr 17, human D6S53E Neighboring gene STARR-positive B cell enhancer ABC_E5599 Neighboring gene BCL2-associated athanogene 6 Neighboring gene proline-rich coiled-coil 2A Neighboring gene predicted gene, 23442

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in high-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of plasma lipoprotein oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of plasma lipoprotein oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within reverse cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of discoidal high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of discoidal high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of low-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spherical high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of very-low-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apolipoprotein M
    Names
    apo-M

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018816.2NP_061286.1  apolipoprotein M precursor

      See identical proteins and their annotated locations for NP_061286.1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28687.1
      UniProtKB/Swiss-Prot
      Q9Z1R3
      UniProtKB/TrEMBL
      Q8VC79
      Related
      ENSMUSP00000025249.7, ENSMUST00000025249.7
      Conserved Domains (1) summary
      cl21528
      Location:1189
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35347973..35350777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)