Ddx46 DEAD box helicase 46 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx46provided by MGI
Official Full Name: DEAD box helicase 46provided by MGI
Primary source: MGI:MGI:1920895
See related: Ensembl:ENSMUSG00000021500 AllianceGenome:MGI:1920895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0801; 2200005K02Rik; 8430438J23Rik
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.8), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55782790..55829080)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55634975..55681267)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDX46 inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus by erasing their m(6)A modification, a modification normally required for export from the nucleus and translation.
Title: The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325430 (e-PCR)
- UniSTS:160307

BE109072 (e-PCR)
- UniSTS:248186

NoName (e-PCR)
- UniSTS:237025

AI957095 (e-PCR)
- UniSTS:165875

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in U2-type prespliceosome assembly	ISO Inferred from Sequence Orthology more info
involved_in U2-type prespliceosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
part_of U2-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2-type spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX46

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box polypeptide 46; DEAD box protein 46

NP_001268984.1

EC 3.6.4.13

XP_006517265.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282055.1 → NP_001268984.1 probable ATP-dependent RNA helicase DDX46

See identical proteins and their annotated locations for NP_001268984.1

Status: VALIDATED

Source sequence(s)

AC126408, BC092240, CJ170754

Consensus CDS

CCDS70464.1

UniProtKB/Swiss-Prot

Q569Z5, Q6ZQ42, Q8R0R6

Related

ENSMUSP00000153328.2, ENSMUST00000223736.2

Conserved Domains (3) summary

COG0513
Location:344 → 826

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00268
Location:378 → 581

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:618 → 714

Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

55782790..55829080

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517202.5 → XP_006517265.1 probable ATP-dependent RNA helicase DDX46 isoform X1

Conserved Domains (2) summary

COG0513
Location:344 → 826

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd17953
Location:361 → 582

DEADc_DDX46; DEAD-box helicase domain of DEAD box protein 46

RNA

XR_004938009.1 RNA Sequence
XR_873437.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145975.3: Suppressed sequence

Description

NM_145975.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.