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    purB adenylosuccinate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945695, updated on 3-Dec-2024

    Summary

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    Official Symbol
    purB
    Official Full Name
    adenylosuccinate lyase
    Primary source
    ECOCYC:EG11314
    Locus tag
    b1131
    See related
    ASAP:ABE-0003810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ade; ade(h); ECK1117
    Summary
    HT_Cmplx33_Cyt: [More information is available at EcoGene: EG11314].
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    Genomic context

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    Sequence:
    NC_000913.3 (1190616..1191986, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L16-arginine 3-hydroxylase Neighboring gene sensor histidine kinase PhoQ Neighboring gene DNA-binding transcriptional dual regulator PhoP Neighboring gene lysogenization regulator Neighboring gene tRNA-specific 2-thiouridylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. Kozlov G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Sep 1. PMID 19724117, Free PMC Article
    2. Nalidixic acid-resistant auxotrophs of Escherichia coli. Helling RB, et al. J Bacteriol, 1970 Nov. PMID 4923064, Free PMC Article
    3. The antimutator phenotype of E. coli mud is only apparent and results from delayed appearance of mutants. Schaaper RM, et al. Mutat Res, 2001 Sep 1. PMID 11506800
    4. Mismatch repair in the antimutator Escherichia coli mud. Dzidić S, et al. Mutat Res, 2003 Jan 28. PMID 12517409
    5. Dihydroneopterin triphosphate epimerase of Escherichia coli: purification, genetic cloning, and expression. Haussmann C, et al. J Bacteriol, 1997 Feb. PMID 9006053, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR.
    2. crystal structures of wild-type Escherichia coli ADL (ec-ADL), and mutant-substrate (H171A-ADS) and -product (H171N-AMP.FUM) complexes to 2.0, 1.85, and 2.0 A resolution, respectively
      Title: Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate lyase
    NP_415649.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1190616..1191986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415649.1 adenylosuccinate lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415649.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AKC3, A0A6C9QCA4, A0A6M9WRH6, A0A8S7B013
      Conserved Domains (1) summary
      PRK09285
      Location:1 → 456
      PRK09285; adenylosuccinate lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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