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    oct-1 Organic cation transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 172841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oct-1
    Official Full Name
    Organic cation transporter 1
    Primary source
    WormBase:WBGene00003842
    Locus tag
    CELE_F52F12.1
    See related
    AllianceGenome:WB:WBGene00003842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables organic cation transmembrane transporter activity. Involved in determination of adult lifespan and organic cation transport. Predicted to be located in membrane. Is expressed in body wall musculature; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; cardiomyopathy; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See oct-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (9888356..9892223, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-5 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter. Wu X, et al. Biochim Biophys Acta, 1999 Apr 14. PMID 10209228
    2. A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries. Papaluca A, et al. Sci Rep, 2016 Oct 27. PMID 27786254, Free PMC Article
    3. Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage. Cheah IK, et al. Free Radic Res, 2013 Dec. PMID 24074059
    4. Complementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of Anthracyclines. Brosseau N, et al. PLoS One, 2015. PMID 26177450, Free PMC Article
    5. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CeOCT-1 related members might be key transporters to facilitate entry of anthracyclines into human cells.
      Title: Complementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of Anthracyclines.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables organic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Organic cation transporter 1
    NP_001021482.1
    • Confirmed by transcript evidence
    NP_492617.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9888356..9892223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060216.6 → NP_492617.4  Organic cation transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492617.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02270, Q9U539
      Conserved Domains (2) summary
      cd06174
      Location:134 → 526
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:34 → 536
      2A0119; cation transport protein

    2. NM_001026311.7 → NP_001021482.1  Organic cation transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U539
      Conserved Domains (2) summary
      cd06174
      Location:117 → 509
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:17 → 519
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U539.3

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