Higd1a HIG1 hypoxia inducible domain family, member 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Higd1aprovided by RGD
Official Full Name: HIG1 hypoxia inducible domain family, member 1Aprovided by RGD
Primary source: RGD:620215
See related: EnsemblRapid:ENSRNOG00000019428 AllianceGenome:RGD:620215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hig1
Summary: Predicted to be involved in mitochondrial respirasome assembly and negative regulation of apoptotic process. Predicted to act upstream of or within several processes, including cellular response to glucose starvation; negative regulation of release of cytochrome c from mitochondria; and positive regulation of protein serine/threonine kinase activity. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 353.7), Muscle (RPKM 232.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130391658..130400888, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121514152..121523382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130482492..130491888, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hgd1a expression in central nervous system varies according to age.
Title: The Expression of Hypoxia-Induced Gene 1 (Higd1a) in the Central Nervous System of Male and Female Rats Differs According to Age.
We found an interesting change in the protein expression pattern, shifting from neurons at P1 to glial cells at P90, which points towards a functional role for this protein in the spinal cord throughout development.
Title: Temporal distribution of Hig-1 (hypoxia-induced gene 1) mRNA and protein in rat spinal cord: changes during postnatal life.
Hig-1 protein and human- and murine-predicted sequences, as well as its characteristic expression in the Central Nervous System, are indicative of a specific role which could be related to apoptosis signaling during postnatal maturation.
Title: Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression.

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General gene information

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Markers

RH132084 (e-PCR)
- UniSTS:215367

AW049839 (e-PCR)
- UniSTS:164430

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respirasome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: HIG1 domain family member 1A, mitochondrial

Names: HIG1 domain family, member 1A; hypoxia induced gene 1; hypoxia-inducible gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.