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    Slc38a1 solute carrier family 38, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170567, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc38a1provided by RGD
    Official Full Name
    solute carrier family 38, member 1provided by RGD
    Primary source
    RGD:69645
    See related
    EnsemblRapid:ENSRNOG00000005291 AllianceGenome:RGD:69645
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ata1; GlnT; Sat1
    Summary
    Enables alanine:sodium symporter activity; glycine:sodium symporter activity; and proline:sodium symporter activity. Involved in several processes, including amino acid import; glutamine metabolic process; and positive regulation of L-glutamine import across plasma membrane. Located in external side of apical plasma membrane and neuronal cell body. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 285.3), Thymus (RPKM 191.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc38a1 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (129612414..129681727, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (127733230..127802541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (137970555..138040098, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093718 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10, pseudogene 13 Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene uncharacterized LOC134479562

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in alanine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in gamma-aminobutyric acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of L-glutamine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium-coupled neutral amino acid symporter 1
    Names
    N-system amino acid transporter 2
    amino acid transporter A1
    amino acid transporter system A1
    glutamine transporter
    rATA1
    sodium-coupled neutral amino acid transporter 1
    system A amino acid transporter 1
    system A transporter 2
    system N amino acid transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138832.1NP_620187.1  sodium-coupled neutral amino acid symporter 1

      See identical proteins and their annotated locations for NP_620187.1

      Status: PROVISIONAL

      Source sequence(s)
      AF075704
      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
      Related
      ENSRNOP00000008138.4, ENSRNOT00000008138.6
      Conserved Domains (1) summary
      cl00456
      Location:69472
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      129612414..129681727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242281.5XP_006242343.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006242343.1

      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
      Conserved Domains (1) summary
      cl00456
      Location:69472
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_063262935.1XP_063119005.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
    3. XM_006242280.5XP_006242342.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006242342.1

      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
      Conserved Domains (1) summary
      cl00456
      Location:69472
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_006242277.5XP_006242339.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006242339.1

      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
      Conserved Domains (1) summary
      cl00456
      Location:69472
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_063262936.1XP_063119006.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM15
      UniProtKB/TrEMBL
      A6KC24
    6. XM_039078321.2XP_038934249.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:3341
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain