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    Arhgap22 Rho GTPase activating protein 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap22provided by RGD
    Official Full Name
    Rho GTPase activating protein 22provided by RGD
    Primary source
    RGD:1307237
    See related
    EnsemblRapid:ENSRNOG00000024728 AllianceGenome:RGD:1307237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction and regulation of postsynapse organization. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 32.0), Lung (RPKM 18.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap22 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8480222..8637823)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8473806..8631552)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9454269..9613508)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene leucine rich repeat containing 18 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482457 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene FERM and PDZ domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2. Valnegri P, et al. Hum Mol Genet, 2011 Dec 15. PMID 21926414, Free PMC Article
    2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107297.1 → NP_001100767.1  rho GTPase-activating protein 22

      See identical proteins and their annotated locations for NP_001100767.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474046
      UniProtKB/TrEMBL
      A6KFU6, D4ABZ7
      Related
      ENSRNOP00000033034.2, ENSRNOT00000035915.4
      Conserved Domains (4) summary
      pfam00169
      Location:29 → 54
      PH; PH domain
      pfam15035
      Location:437 → 529
      Rootletin; Ciliary rootlet component, centrosome cohesion
      cl02570
      Location:61 → 190
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      8480222..8637823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275358.1 → XP_063131428.1  rho GTPase-activating protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKJ1
      Related
      ENSRNOP00000096403.2, ENSRNOT00000101853.2

    2. XM_039094464.2 → XP_038950392.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKJ1, A0A8I6APD0
      Conserved Domains (3) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      TIGR02168
      Location:614 → 704
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:42 → 157
      PH-like; Pleckstrin homology-like domain

    3. XM_017600084.3 → XP_017455573.1  rho GTPase-activating protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKJ1
      Conserved Domains (4) summary
      cd04390
      Location:157 → 355
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:44 → 150
      PH; PH domain
      pfam15035
      Location:602 → 694
      Rootletin; Ciliary rootlet component, centrosome cohesion
      cl17171
      Location:42 → 157
      PH-like; Pleckstrin homology-like domain

    4. XM_063275360.1 → XP_063131430.1  rho GTPase-activating protein 22 isoform X7

    5. XM_039094467.2 → XP_038950395.1  rho GTPase-activating protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKJ1
      Related
      ENSRNOP00000068839.2, ENSRNOT00000082208.3
      Conserved Domains (3) summary
      cd04390
      Location:167 → 365
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      TIGR02168
      Location:608 → 698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:36 → 151
      PH-like; Pleckstrin homology-like domain

    6. XM_063275359.1 → XP_063131429.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JTT7, A0A8I5ZKJ1

    7. XM_063275361.1 → XP_063131431.1  rho GTPase-activating protein 22 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZKJ1

    8. XM_039094469.2 → XP_038950397.1  rho GTPase-activating protein 22 isoform X6

      Conserved Domains (2) summary
      TIGR02168
      Location:397 → 487
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl02570
      Location:1 → 154
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    9. XM_006252751.5 → XP_006252813.1  rho GTPase-activating protein 22 isoform X5

      Conserved Domains (2) summary
      cd04390
      Location:33 → 231
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam15035
      Location:478 → 570
      Rootletin; Ciliary rootlet component, centrosome cohesion
    Nucleotide Protein Strain
    Heading Accession and Version

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