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    Dcaf8 DDB1 and CUL4 associated factor 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf8provided by RGD
    Official Full Name
    DDB1 and CUL4 associated factor 8provided by RGD
    Primary source
    RGD:1308513
    See related
    EnsemblRapid:ENSRNOG00000006785 AllianceGenome:RGD:1308513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr42a; RGD1308513
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 281.3), Kidney (RPKM 236.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf8 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87141940..87199859)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84609838..84667025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90532153..90587542)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit alpha Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene proliferation and apoptosis adaptor protein 15 Neighboring gene calsequestrin 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). Wu F, et al. FEBS Lett, 2012 Apr 24. PMID 22500989
    2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within myotube cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 8
    Names
    WD repeat domain 42A
    WD repeat-containing protein 42A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014231.2 → NP_001014253.1  DDB1- and CUL4-associated factor 8 isoform 1

      See identical proteins and their annotated locations for NP_001014253.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5U2M6
      UniProtKB/TrEMBL
      A0A8L2Q3J7, A6JG32
      Related
      ENSRNOP00000070721.1, ENSRNOT00000082469.3
      Conserved Domains (3) summary
      COG2319
      Location:183 → 499
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:192 → 228
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:183 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001429912.1 → NP_001416841.1  DDB1- and CUL4-associated factor 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5U2M6
      UniProtKB/TrEMBL
      A0A8L2Q3J7, A6JG32

    3. NM_001429913.1 → NP_001416842.1  DDB1- and CUL4-associated factor 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5U2M6
      UniProtKB/TrEMBL
      A0A8L2Q3J7, A6JG32

    4. NM_001429914.1 → NP_001416843.1  DDB1- and CUL4-associated factor 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JYN0

    5. NM_001429915.1 → NP_001416844.1  DDB1- and CUL4-associated factor 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JYN0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      87141940..87199859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250297.5 → XP_006250359.1  DDB1- and CUL4-associated factor 8 isoform X1

      Related
      ENSRNOP00000095537.2, ENSRNOT00000101398.2
      Conserved Domains (3) summary
      COG2319
      Location:183 → 499
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:192 → 228
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:183 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063272522.1 → XP_063128592.1  DDB1- and CUL4-associated factor 8 isoform X3

    3. XM_063272520.1 → XP_063128590.1  DDB1- and CUL4-associated factor 8 isoform X2

    4. XM_006250298.4 → XP_006250360.1  DDB1- and CUL4-associated factor 8 isoform X1

      Related
      ENSRNOP00000008944.6, ENSRNOT00000008944.9
      Conserved Domains (3) summary
      COG2319
      Location:183 → 499
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:192 → 228
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:183 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_010056926.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2M6.1 GenPept UniProtKB/Swiss-Prot:Q5U2M6

    Gene LinkOut

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