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    Fbxl19 F-box and leucine-rich repeat protein 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308999, updated on 9-Dec-2024

    Summary

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    Symbol
    Fbxl19provided by RGD
    Full Name
    F-box and leucine-rich repeat protein 19provided by RGD
    Primary source
    RGD:1310989
    See related
    EnsemblRapid:ENSRNOG00000018986 AllianceGenome:RGD:1310989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ubiquitin-like ligase-substrate adaptor activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL19 (F-box and leucine rich repeat protein 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 68.4), Testes (RPKM 60.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl19 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191786981..191811314)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182356899..182380839)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199196126..199217147)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BAF chromatin remodeling complex subunit BCL7C Neighboring gene microRNA 762 Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2 Neighboring gene uncharacterized LOC134483922 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A, histone lysine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Zhao J, et al. Nat Immunol, 2012 Jun 3. PMID 22660580, Free PMC Article
    2. DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Xu C, et al. Structure, 2018 Jan 2. PMID 29276034
    3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415928.1 → NP_001402857.1  F-box/LRR-repeat protein 19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2KB30
      Related
      ENSRNOP00000059635.2, ENSRNOT00000065187.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191786981..191811314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078403.2 → XP_038934331.1  F-box/LRR-repeat protein 19 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KB30
      Conserved Domains (5) summary
      cd09293
      Location:446 → 645
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:466 → 489
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67 → 128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:30 → 57
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:404 → 445
      F-box-like

    2. XM_039078404.2 → XP_038934332.1  F-box/LRR-repeat protein 19 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KB30
      Conserved Domains (5) summary
      cd09293
      Location:446 → 645
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:466 → 489
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67 → 128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:30 → 57
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:404 → 445
      F-box-like

    3. XM_006230278.5 → XP_006230340.1  F-box/LRR-repeat protein 19 isoform X4

      Conserved Domains (5) summary
      cd09293
      Location:438 → 637
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:95 → 122
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:458 → 481
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:132 → 193
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:396 → 439
      F-box-like; F-box-like

    4. XM_006230279.5 → XP_006230341.1  F-box/LRR-repeat protein 19 isoform X5

      UniProtKB/TrEMBL
      A6I9T8, D4A2L9
      Conserved Domains (5) summary
      cd09293
      Location:395 → 594
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:95 → 122
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:415 → 438
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:132 → 193
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:353 → 396
      F-box-like; F-box-like

    5. XM_006230277.5 → XP_006230339.1  F-box/LRR-repeat protein 19 isoform X2

      Conserved Domains (5) summary
      cd09293
      Location:468 → 667
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:95 → 122
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:488 → 511
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:132 → 193
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:426 → 469
      F-box-like; F-box-like

    6. XM_006230276.5 → XP_006230338.1  F-box/LRR-repeat protein 19 isoform X1

      Related
      ENSRNOP00000075629.2, ENSRNOT00000090428.3
      Conserved Domains (5) summary
      cd09293
      Location:511 → 710
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:95 → 122
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:531 → 554
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:132 → 193
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:469 → 512
      F-box-like; F-box-like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107552.1: Suppressed sequence

      Description
      NM_001107552.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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