Tas1r1 taste receptor, type 1, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tas1r1provided by MGI
Official Full Name: taste receptor, type 1, member 1provided by MGI
Primary source: MGI:MGI:1927505
See related: Ensembl:ENSMUSG00000028950 AllianceGenome:MGI:1927505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR1; T1r1; Gpr70
Summary: Predicted to enable G protein-coupled receptor activity and taste receptor activity. Predicted to be involved in sensory perception of umami taste. Predicted to be active in plasma membrane. Is expressed in tongue anterior part. Orthologous to human TAS1R1 (taste 1 receptor member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 16.2), genital fat pad adult (RPKM 1.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 82.83 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152112371..152122947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (152027914..152038490, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Title: Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice.
Title: Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice.
Tas1r3 knockout leads to reduction in the size of pancreatic islets and their density in pancreatic tissue.
Title: The Effect of the Taste Receptor Protein T1R3 on the Development of Islet Tissue of the Murine Pancreas.
RNAi-mediated depletion of Sp4 and Klf5 decreased Tas1r1 expression, while overexpression of Klf5, but not Sp4, significantly increased Tas1r1 expression in the myoblast cells.
Title: Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells.
this study shows that taste receptor T1R1 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells
Title: Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells.
residual sensitivity by the T1R1+T1R3 KO mice demonstrates that a T1R-independent mechanism can contribute to the detectability of high concentrations of this prototypical umami compound stimulus
Title: Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.
T1R1/T1R3 modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo.
Title: Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland.
siRNA silencing of T1R1 repressed beta-casein synthesis in HC11 cells both with and without essential amino acids present in the culture medium. T1R1/T1R3 serves as sensor of extracellular amino acids in mouse mammary epithelial cells and involved in milk protein synthesis regulation.
Title: Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3.
T1R1/T1R3 have roles in regulating ERK1/2 and mTORC1 in MIN6 cells
Title: Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.
Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice
Title: Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Markers

Gpr70 (e-PCR), detects polymorphism
- UniSTS:226052

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of umami taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of umami taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: taste receptor type 1 member 1

Names: G-protein coupled receptor 70; candidate taste receptor T1R1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031867.2 → NP_114073.1 taste receptor type 1 member 1 precursor

See identical proteins and their annotated locations for NP_114073.1

Status: VALIDATED

Source sequence(s)

AF337040

Consensus CDS

CCDS18985.1

UniProtKB/Swiss-Prot

Q6NS58, Q923J9, Q925I5, Q99PG5, Q99PG6

UniProtKB/TrEMBL

Q3U5H1

Related

ENSMUSP00000030792.2, ENSMUST00000030792.2

Conserved Domains (4) summary

cd06363
Location:33 → 487

PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor

pfam00003
Location:589 → 815

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:75 → 458

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:495 → 545

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

152112371..152122947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538474.5 → XP_006538537.1 taste receptor type 1 member 1 isoform X1

UniProtKB/Swiss-Prot

Q6NS58, Q923J9, Q925I5, Q99PG5, Q99PG6

Conserved Domains (4) summary

cd14964
Location:476 → 497

7tm_GPCRs; TM helix 2 [structural motif]

pfam07562
Location:367 → 419

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:33 → 367

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl28897
Location:462 → 691

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily