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    PA2019 multidrug efflux lipoprotein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878839, updated on 24-Aug-2024

    Summary

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    Gene symbol
    PA2019
    Gene description
    multidrug efflux lipoprotein
    Locus tag
    PA2019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2211322..2212512, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene multidrug efflux protein Neighboring gene transcriptional regulator Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7. Morita Y, et al. Microbiology (Reading), 2012 Apr. PMID 22282519
    2. Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa. Yamamoto M, et al. Microbiology (Reading), 2009 Oct. PMID 19589837
    3. Roles of MexXY- and MexAB-multidrug efflux pumps in intrinsic multidrug resistance of Pseudomonas aeruginosa PAO1. Morita Y, et al. J Gen Appl Microbiol, 2001 Feb. PMID 12483565
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MexXY multidrug efflux pump was shown to enhance the effect of aminoglycoside modifying enzymes to develop high-level aminoglycoside resistance in Pseudomonas aeruginosa.
      Title: Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7.
    2. Gel shift analyses and in vitro transcription assays revealed that interaction between PA5471 and MexZ reduced MexZ DNA-binding ability, leading to mexXY transcription.
      Title: Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
    3. Mutants of mexXY show increased susceptibility to aminoglycosides, erythromycin, and tetracycline while expression in P. aeruginosa increased the resistance to fluoroquinolones.
      Title: Roles of MexXY- and MexAB-multidrug efflux pumps in intrinsic multidrug resistance of Pseudomonas aeruginosa PAO1.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    multidrug efflux lipoprotein
    NP_250709.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2211322..2212512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250709.1 multidrug efflux lipoprotein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250709.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9ZH25
      Conserved Domains (1) summary
      PRK09578
      Location:3 → 387
      PRK09578; MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit
    Nucleotide Protein
    Heading Accession and Version

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