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    PVX_100730 serine hydroxymethyltransferase, putative [ Plasmodium vivax (malaria parasite P. vivax) ]

    Gene ID: 5473173, updated on 5-Sep-2024

    Summary

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    Gene symbol
    PVX_100730
    Gene description
    serine hydroxymethyltransferase, putative
    Locus tag
    PVX_100730
    See related
    PlasmoDB:PVX_100730; VEuPathDB:PVX_100730
    Gene type
    protein coding
    RNA name
    serine hydroxymethyltransferase, putative
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium vivax (strain: Salvador I)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Plasmodium)
    Orthologs
    Plasmodium falciparum all
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    Genomic context

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    See PVX_100730 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Sequence:
    Chromosome: 14; NC_009919.1 (2335451..2337653)

    Chromosome 14 - NC_009919.1Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene tRNA-Gln Neighboring gene hypothetical protein Neighboring gene ATP synthase beta chain, mitochondrial precursor, putative Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009919.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase. Maenpuen S, et al. J Biol Chem, 2015 Mar 27. PMID 25678710, Free PMC Article
    2. Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control. Chitnumsub P, et al. Acta Crystallogr D Biol Crystallogr, 2014 Dec 1. PMID 25478836, Free PMC Article
    3. Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior. Amornwatcharapong W, et al. Arch Biochem Biophys, 2017 Sep 15. PMID 28760597
    4. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Carlton JM, et al. Nature, 2008 Oct 9. PMID 18843361, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
      Title: Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior.
    2. The crystal structures of serine hydroxymethyltransferase in a binary complex with L-serine and in a ternary complex with D-serine (D-Ser) and (6R)-5-formyltetrahydrofolate provide clues to the mechanism underlying the control of enzyme activity.
      Title: Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.
    3. Serine conversion and glycine formation kinetcs of Plasmodium vivax serine hydroxymethyltransferase.
      Title: Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Repeated regions

    • Loc: 2337498-2337521 rpt_type = tandem , rpt_unit_seq = tttta , satellite = microsatellite

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, putative
    XP_001613892.1
    • encoded by transcript PVX_100730A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009919.1 Reference assembly

      Range
      2335451..2337653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001613842.1 → XP_001613892.1  serine hydroxymethyltransferase, putative [Plasmodium vivax]

      See identical proteins and their annotated locations for XP_001613892.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0J9S3R9, A0A0J9SRM8, A0A0J9T4H6, A0A0J9W7T1, A0A1G4H5I1, A5K8L9
      Conserved Domains (1) summary
      PTZ00094
      Location:1 → 442
      PTZ00094; serine hydroxymethyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5XMS_A.1
    5XMS_B.1
    5XMS_C.1
    5XMT_A.1
    5XMT_B.1
    5XMT_C.1
    5XMU_A.1
    5XMU_B.1
    5XMU_C.1
    5XMV_A.1
    5XMV_B.1
    5XMV_C.1
    5YFY_A.1
    5YFY_B.1
    5YFY_C.1
    5YFZ_A.1
    5YFZ_B.1
    5YFZ_C.1
    5YG0_A.1
    5YG0_B.1
    5YG0_C.1
    5YG1_A.1
    5YG1_B.1
    5YG1_C.1
    5YG2_A.1
    5YG2_B.1
    5YG2_C.1
    5YG3_A.1
    5YG3_B.1
    5YG3_C.1
    5YG4_A.1
    5YG4_B.1
    5YG4_C.1

    Gene LinkOut

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    Research Materials