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    RGS16 regulator of G protein signaling 16 [ Homo sapiens (human) ]

    Gene ID: 6004, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RGS16provided by HGNC
    Official Full Name
    regulator of G protein signaling 16provided by HGNC
    Primary source
    HGNC:HGNC:9997
    See related
    Ensembl:ENSG00000143333 MIM:602514; AllianceGenome:HGNC:9997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGS-R; A28-RGS14; A28-RGS14P
    Summary
    The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 20.2), lung (RPKM 3.6) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS16 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182598623..182604389, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (181958121..181963886, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182567758..182573524, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:182419119-182419726 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:182443692-182444891 Neighboring gene regulator of G protein signaling like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2198 Neighboring gene ribonuclease L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182584000-182584897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182584926-182585474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182585475-182586022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2205 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182612621-182613820 Neighboring gene regulator of G protein signaling 8 Neighboring gene long intergenic non-protein coding RNA 1688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The regulator of G protein signaling family. De Vries L, et al. Annu Rev Pharmacol Toxicol, 2000. PMID 10836135
    2. Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling. Shen H, et al. Cell Death Dis, 2024 Jun 21. PMID 38906869, Free PMC Article
    3. Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis. Zhu F, et al. Eur J Gastroenterol Hepatol, 2022 Oct 1. PMID 35830366, Free PMC Article
    4. RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. Liang G, et al. J Biol Chem, 2009 Aug 7. PMID 19509421, Free PMC Article
    5. RGS16 promotes glioma progression and serves as a prognostic factor. Huang R, et al. CNS Neurosci Ther, 2020 Aug. PMID 32319728, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling.
      Title: Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling.
    2. RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration.
      Title: RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration.
    3. RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.
      Title: RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.
    4. Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10.
      Title: Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10.
    5. Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis.
      Title: Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis.
    6. RGS16 promotes glioma progression and serves as a prognostic factor.
      Title: RGS16 promotes glioma progression and serves as a prognostic factor.
    7. Data show that bothregulator of G protein signaling (RGS16 and RGS18) inhibit protease-activated receptor 2 (PAR2)/G-protein, Gi-Go subunits (Galphai/o) -mediated signaling.
      Title: The regulators of G protein signaling RGS16 and RGS18 inhibit protease-activated receptor 2/Gi/o signaling through distinct interactions with Gα in live cells.
    8. Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW]
      Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
    9. The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16.
      Title: miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.
    10. suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
      Title: The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 16
    Names
    hRGS-r
    regulator of G-protein signalling 16
    retinal-specific RGS
    retinally abundant regulator of G-protein signaling

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002928.4 → NP_002919.3  regulator of G-protein signaling 16

      See identical proteins and their annotated locations for NP_002919.3

      Status: REVIEWED

      Source sequence(s)
      AL353778, BC006243, DA060276, DC349953
      Consensus CDS
      CCDS1348.1
      UniProtKB/Swiss-Prot
      B2R4M4, O15492, Q5VYN9, Q99701
      Related
      ENSP00000356529.5, ENST00000367558.6
      Conserved Domains (1) summary
      cd08710
      Location:66 → 179
      RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      182598623..182604389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448796.1 → XP_024304564.1  regulator of G-protein signaling 16 isoform X1

      Conserved Domains (1) summary
      cd08710
      Location:65 → 178
      RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      181958121..181963886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338046.1 → XP_054194021.1  regulator of G-protein signaling 16 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15492.2 GenPept UniProtKB/Swiss-Prot:O15492

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