aos-1 SUMO-activating enzyme subunit aos-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aos-1
Official Full Name: SUMO-activating enzyme subunit aos-1
Primary source: WormBase:WBGene00000142
Locus tag: CELE_C08B6.9
See related: AllianceGenome:WB:WBGene00000142
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Contributes to SUMO activating enzyme activity. Involved in protein sumoylation. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aos-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (10127492..10130295, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08B6.9 (e-PCR)
- UniSTS:308998

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to SUMO activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SUMO activating enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SUMO activating enzyme complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SUMO-activating enzyme subunit aos-1

NP_505604.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10127492..10130295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073203.6 → NP_505604.2 SUMO-activating enzyme subunit aos-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17820

Conserved Domains (1) summary

cd01485
Location:17 → 345

E1-1_like; Ubiquitin activating enzyme (E1), repeat 1-like. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), ...