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    Steap1 STEAP family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297738, updated on 9-Dec-2024

    Summary

    Official Symbol
    Steap1provided by RGD
    Official Full Name
    STEAP family member 1provided by RGD
    Primary source
    RGD:1311543
    See related
    EnsemblRapid:ENSRNOG00000000017 AllianceGenome:RGD:1311543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Steap
    Summary
    Predicted to enable heme binding activity. Predicted to be active in endosome and plasma membrane. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 58.2), Uterus (RPKM 14.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Steap1 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29231809..29242317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28276972..28287484)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25435885..25446393)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 2, pseudogene 1 Neighboring gene high mobility group box 3 like 2 Neighboring gene uncharacterized LOC134486556 Neighboring gene STEAP2 metalloreductase Neighboring gene cilia and flagella associated protein 69

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables cupric reductase (NADH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables ferric-chelate reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within copper ion import ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    STEAP1 protein
    Names
    metalloreductase STEAP1
    six transmembrane epithelial antigen of the prostate 1
    NP_001100099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106629.1NP_001100099.1  STEAP1 protein

      See identical proteins and their annotated locations for NP_001100099.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474013
      UniProtKB/TrEMBL
      A6K252, D3ZEK7
      Related
      ENSRNOP00000000018.4, ENSRNOT00000000018.9
      Conserved Domains (1) summary
      pfam01794
      Location:121264
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      29231809..29242317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)