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    Ptk6 protein tyrosine kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366275, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ptk6provided by RGD
    Official Full Name
    protein tyrosine kinase 6provided by RGD
    Primary source
    RGD:1309098
    See related
    EnsemblRapid:ENSRNOG00000012987 AllianceGenome:RGD:1309098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to retinoic acid; negative regulation of protein tyrosine kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and ruffle. Predicted to be active in plasma membrane. Orthologous to human PTK6 (protein tyrosine kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 21.2) and Lung (RPKM 1.8) See more
    Orthologs
    NEW
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    Genomic context

    See Ptk6 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188684633..188693224, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168307073..168315664, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176698305..176706896, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486215 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene uncharacterized LOC108350541 Neighboring gene fibronectin type III domain containing 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-tyrosine kinase 6
    Names
    PTK6 protein tyrosine kinase 6
    NP_001102438.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108968.1NP_001102438.1  protein-tyrosine kinase 6

      See identical proteins and their annotated locations for NP_001102438.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474066
      UniProtKB/TrEMBL
      A6KM34, D3ZDS3
      Related
      ENSRNOP00000017337.4, ENSRNOT00000017337.6
      Conserved Domains (4) summary
      cd10358
      Location:75174
      SH2_PTK6_Brk; Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
      cd11847
      Location:1269
      SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
      smart00221
      Location:192441
      STYKc; Protein kinase; unclassified specificity
      cl21453
      Location:184444
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188684633..188693224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)