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    Mfhas1 multifunctional ROCO family signaling regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfhas1provided by RGD
    Official Full Name
    multifunctional ROCO family signaling regulator 1provided by RGD
    Primary source
    RGD:1308812
    See related
    EnsemblRapid:ENSRNOG00000011431 AllianceGenome:RGD:1308812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; protein phosphatase 2A binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including erythrocyte differentiation; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in cytoplasm. Orthologous to human MFHAS1 (multifunctional ROCO family signaling regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.8), Brain (RPKM 48.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfhas1 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (63248833..63336441, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (56545462..56633649, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (60120457..60208550, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein like 1 Neighboring gene Tu translation elongation factor, mitochondrial, pseudogene 1 Neighboring gene uncharacterized LOC120097469 Neighboring gene uncharacterized LOC134482392 Neighboring gene uncharacterized LOC134482393 Neighboring gene uncharacterized LOC120097472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High Glucose Stimulates Expression of MFHAS1 to Mitigate Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein Endothelial Cells. Wang HH, et al. Inflammation, 2018 Mar. PMID 29168081
    2. Identification of a novel gene, MASL1, within an amplicon at 8p23.1 detected in malignant fibrous histiocytomas by comparative genomic hybridization. Sakabe T, et al. Cancer Res, 1999 Feb 1. PMID 9973190
    3. MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-κB Signaling Pathway Following Negative Regulation. Zhong J, et al. PLoS One, 2015. PMID 26599367, Free PMC Article
    4. GTP binding controls complex formation by the human ROCO protein MASL1. Dihanich S, et al. FEBS J, 2014 Jan. PMID 24286120, Free PMC Article
    5. MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239. Shi Q, et al. Mol Immunol, 2017 Aug. PMID 28609714

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    malignant fibrous histiocytoma-amplified sequence 1
    Names
    malignant fibrous histiocytoma amplified sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107316.1 → NP_001100786.1  malignant fibrous histiocytoma-amplified sequence 1

      See identical proteins and their annotated locations for NP_001100786.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A6IVM6, D3ZJL1
      Related
      ENSRNOP00000015203.4, ENSRNOT00000015203.6
      Conserved Domains (5) summary
      cd00116
      Location:107 → 350
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:109 → 132
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:247 → 304
      LRR_8; Leucine rich repeat
      pfam16095
      Location:656 → 902
      COR; C-terminal of Roc, COR, domain
      cl21455
      Location:405 → 548
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      63248833..63336441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253224.5 → XP_006253286.1  malignant fibrous histiocytoma-amplified sequence 1 isoform X1

      See identical proteins and their annotated locations for XP_006253286.1

      UniProtKB/TrEMBL
      A0A8I5ZRZ8, A6IVM5
      Related
      ENSRNOP00000081189.1, ENSRNOT00000098060.2
      Conserved Domains (4) summary
      COG4886
      Location:42 → 338
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:109 → 132
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:656 → 902
      COR; C-terminal of Roc, COR, domain
      cl38936
      Location:405 → 548
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006253227.5 → XP_006253289.1  malignant fibrous histiocytoma-amplified sequence 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZT22
      Related
      ENSRNOP00000080425.1, ENSRNOT00000108535.2
      Conserved Domains (5) summary
      cd00116
      Location:107 → 350
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:109 → 132
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:247 → 304
      LRR_8; Leucine rich repeat
      pfam16095
      Location:656 → 902
      COR; C-terminal of Roc, COR, domain
      cl21455
      Location:405 → 548
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_001841536.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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