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    APMAP adipocyte plasma membrane associated protein [ Homo sapiens (human) ]

    Gene ID: 57136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APMAPprovided by HGNC
    Official Full Name
    adipocyte plasma membrane associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13238
    See related
    Ensembl:ENSG00000101474 MIM:615884; AllianceGenome:HGNC:13238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BSCv; C20orf3
    Summary
    Enables arylesterase activity. Predicted to be involved in biosynthetic process. Located in cell surface and membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 46.5), fat (RPKM 34.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See APMAP in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (24962925..24992751, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25027196..25056965, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (24943561..24973387, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24899137-24899770 Neighboring gene long intergenic non-protein coding RNA 2967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17653 Neighboring gene cystatin F Neighboring gene RNA, U6 small nuclear 1257, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24960021-24960521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24961283-24961783 Neighboring gene H3K27ac hESC enhancers GRCh37_chr20:24972940-24973440 and GRCh37_chr20:24973441-24973941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17657 Neighboring gene acyl-CoA synthetase short chain family member 1 Neighboring gene Sharpr-MPRA regulatory region 14776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25038651-25039256 Neighboring gene uncharacterized LOC124904882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a Novel Function of Adipocyte Plasma Membrane-Associated Protein (APMAP) in Gestational Diabetes Mellitus by Proteomic Analysis of Omental Adipose Tissue. Ma Y, et al. J Proteome Res, 2016 Feb 5. PMID 26767403
    2. Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells. Haley SA, et al. Virology, 2020 Sep. PMID 32838939, Free PMC Article
    3. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Mosser S, et al. Hum Mol Genet, 2015 Jan 15. PMID 25180020, Free PMC Article
    4. Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection. Ye X, et al. PLoS Pathog, 2019 Jul. PMID 31356650, Free PMC Article
    5. Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer. Mekenkamp LJ, et al. Gut, 2013 Jan. PMID 22267596

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
      Title: Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
    2. Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells.
      Title: Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells.
    3. results suggest that APMAP functions as a modulator promoting human cytomegalovirus (HCMV) infection in multiple cell types and is an important player in the complex HCMV infection mechanism
      Title: Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.
    4. These data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance.
      Title: APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
    5. APMAP is an endogenous suppressor of Abeta production in the brain.
      Title: The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.
    6. C20orf3 mapping at chromosome 20p11 is associated with hepatic-specific metastasis in patients with colorectal cancer.
      Title: Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer.
    7. characterization of the gene product of open reading frame 3 encoded at human chromosome 20 (C20orf3), which represents a member of the lactonohydrolase super family
      Title: Localization and characterization of the novel protein encoded by C20orf3.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables strictosidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adipocyte plasma membrane-associated protein
    Names
    protein BSCv

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020531.3 → NP_065392.1  adipocyte plasma membrane-associated protein

      See identical proteins and their annotated locations for NP_065392.1

      Status: VALIDATED

      Source sequence(s)
      AK026866, AL035661, BG773501, CF131759
      Consensus CDS
      CCDS13166.1
      UniProtKB/Swiss-Prot
      A8K514, B4DXG1, Q6UVZ8, Q9GZS8, Q9HDC9, Q9NUB2
      UniProtKB/TrEMBL
      H0Y512
      Related
      ENSP00000217456.2, ENST00000217456.3
      Conserved Domains (4) summary
      COG3386
      Location:73 → 320
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cd05819
      Location:102 → 137
      NHL; NHL repeat [structural motif]
      cl18310
      Location:96 → 284
      NHL; NHL repeat unit of beta-propeller proteins
      cl22863
      Location:201 → 288
      Str_synth; Strictosidine synthase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      24962925..24992751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260763.4 → XP_005260820.1  adipocyte plasma membrane-associated protein isoform X1

      UniProtKB/Swiss-Prot
      Q9HDC9
      Conserved Domains (3) summary
      cd05819
      Location:102 → 137
      NHL; NHL repeat [structural motif]
      cl18310
      Location:96 → 282
      NHL; NHL repeat unit of beta-propeller proteins
      cl22863
      Location:201 → 287
      Str_synth; Strictosidine synthase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      25027196..25056965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323725.1 → XP_054179700.1  adipocyte plasma membrane-associated protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HDC9.2 GenPept UniProtKB/Swiss-Prot:Q9HDC9

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