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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001145648.3 → NP_001139120.1 ras-specific guanine nucleotide-releasing factor 1 isoform 3
See identical proteins and their annotated locations for NP_001139120.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
- Source sequence(s)
-
AC011944, AK226101, AL355696, BC040275, DA126882
- Consensus CDS
-
CCDS45320.1
- UniProtKB/TrEMBL
-
Q8IUU5
- Related
- ENSP00000452781.2, ENST00000558480.7
- Conserved Domains (6) summary
-
- smart00147
Location:1018 → 1254
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- smart00325
Location:244 → 425
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd13261
Location:19 → 154
- PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
- pfam00618
Location:634 → 682
- RasGEF_N; RasGEF N-terminal motif
- cl02520
Location:922 → 991
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- cl17171
Location:431 → 582
- PH-like; Pleckstrin homology-like domain
-
NM_002891.6 → NP_002882.3 ras-specific guanine nucleotide-releasing factor 1 isoform 1
See identical proteins and their annotated locations for NP_002882.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC011944, AK226101, AK290135, AL355696, DA126882
- Consensus CDS
-
CCDS10309.1
- UniProtKB/Swiss-Prot
- F8VPA5, H0YKF2, J3KQP9, Q13972, Q16027
- UniProtKB/TrEMBL
-
Q8IUU5
- Related
- ENSP00000405963.3, ENST00000419573.7
- Conserved Domains (7) summary
-
- smart00147
Location:1034 → 1270
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- smart00325
Location:244 → 425
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd13261
Location:19 → 154
- PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
- pfam00169
Location:24 → 129
- PH; PH domain
- pfam00618
Location:647 → 695
- RasGEF_N; RasGEF N-terminal motif
- cl02520
Location:938 → 1007
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- cl17171
Location:431 → 582
- PH-like; Pleckstrin homology-like domain
-
NM_153815.3 → NP_722522.1 ras-specific guanine nucleotide-releasing factor 1 isoform 2
See identical proteins and their annotated locations for NP_722522.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks multiple 5' exon, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AC011944, AK226101, AL355696
- Consensus CDS
-
CCDS42065.1
- UniProtKB/Swiss-Prot
-
Q13972
- Related
- ENSP00000378228.3, ENST00000394745.3
- Conserved Domains (2) summary
-
- smart00147
Location:250 → 486
- RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
- cl02520
Location:154 → 223
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000015.10 Reference GRCh38.p14 Primary Assembly
- Range
-
78959906..79090780 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017022456.3 → XP_016877945.1 ras-specific guanine nucleotide-releasing factor 1 isoform X3
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_017022455.3 → XP_016877944.1 ras-specific guanine nucleotide-releasing factor 1 isoform X1
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_047432926.1 → XP_047288882.1 ras-specific guanine nucleotide-releasing factor 1 isoform X6
-
XM_017022458.3 → XP_016877947.1 ras-specific guanine nucleotide-releasing factor 1 isoform X5
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_017022457.3 → XP_016877946.1 ras-specific guanine nucleotide-releasing factor 1 isoform X4
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_011521866.4 → XP_011520168.1 ras-specific guanine nucleotide-releasing factor 1 isoform X2
- UniProtKB/TrEMBL
-
Q8IUU5
- Conserved Domains (7) summary
-
- smart00325
Location:244 → 425
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd13261
Location:19 → 154
- PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
- pfam00169
Location:24 → 129
- PH; PH domain
- pfam00617
Location:1041 → 1181
- RasGEF; RasGEF domain
- pfam00618
Location:647 → 695
- RasGEF_N; RasGEF N-terminal motif
- cl02520
Location:938 → 1007
- REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
- cl17171
Location:431 → 582
- PH-like; Pleckstrin homology-like domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060939.1 Alternate T2T-CHM13v2.0
- Range
-
76823565..76954487 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054378577.1 → XP_054234552.1 ras-specific guanine nucleotide-releasing factor 1 isoform X3
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_054378576.1 → XP_054234551.1 ras-specific guanine nucleotide-releasing factor 1 isoform X1
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_054378575.1 → XP_054234550.1 ras-specific guanine nucleotide-releasing factor 1 isoform X10
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_054378574.1 → XP_054234549.1 ras-specific guanine nucleotide-releasing factor 1 isoform X9
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_054378573.1 → XP_054234548.1 ras-specific guanine nucleotide-releasing factor 1 isoform X8
- UniProtKB/TrEMBL
-
Q8IUU5
-
XM_054378572.1 → XP_054234547.1 ras-specific guanine nucleotide-releasing factor 1 isoform X7
- UniProtKB/TrEMBL
-
Q8IUU5