Ptprv protein tyrosine phosphatase receptor type V [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprvprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Vprovided by MGI
Primary source: MGI:MGI:108027
See related: Ensembl:ENSMUSG00000097993 AllianceGenome:MGI:108027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Esp; OST; OST-PTP
Summary: Enables protein tyrosine phosphatase activity. Acts upstream of or within several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of insulin secretion; and type B pancreatic cell proliferation. Predicted to be located in membrane. Is expressed in several structures, including early conceptus; embryo mesenchyme; gonad; limb ectoderm; and skeleton. Orthologous to human PTPRVP (protein tyrosine phosphatase receptor type V, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Biased expression in ovary adult (RPKM 6.0), limb E14.5 (RPKM 4.0) and 11 other tissues See more
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Genomic context

Location:: 1 E4; 1 58.24 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (135036236..135060313, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (135108498..135132575, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of the OST gene may be important during skeletogenesis, potentially from commitment of mesenchymal cells to the ossification of new bones; early in embryogenesis, regulation of OST expression may be independent of Runx2/Cbfa1
Title: The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse.
Ptprv is a new direct p53 target and a key mediator of p53-induced cell cycle arrest. Ptprv acts to suppress tumor formation in vivo.
Title: G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548168

Ptprv (e-PCR), detects polymorphism
- UniSTS:525938

Ptprv (e-PCR), detects polymorphism
- UniSTS:525939

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein carboxylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase V

Names: ES cell phosphatase; R-PTP-V; embryonic stem cell protein-tyrosine phosphatase; tyrosine phosphatase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007955.3 → NP_031981.3 receptor-type tyrosine-protein phosphatase V precursor

Status: VALIDATED

Description

Transcript Variant: This represents a protein-coding allele found in the NOD strain.

Source sequence(s)

AK156112

UniProtKB/TrEMBL

Q9ERK5

Conserved Domains (6) summary

smart00060
Location:473 → 551

FN3; Fibronectin type 3 domain

smart00194
Location:1150 → 1408

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1176 → 1408

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:656 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:36 → 109

fn3; Fibronectin type III domain

cl21483
Location:1521 → 1692

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

NR_153383.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This represents a non-coding allele found in the reference strain.

Source sequence(s)

AC133097

Related

ENSMUST00000183317.8