Vrp1 Verprolin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vrp1provided by FlyBase
Official Full Name: Verprolin 1provided by FlyBase
Primary source: FLYBASE:FBgn0243516
Locus tag: Dmel_CG13503
See related: AllianceGenome:FB:FBgn0243516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13503; D-WIP; Dmel\CG13503; Dm_Vrp1; dwip; dWIP; DWip; DWiP; DWIP; sltr; Sltr; solas; vrp; vrp1; wip; Wip; WIP
Summary: Enables actin filament binding activity. Involved in several processes, including behavioral response to ethanol; myoblast fusion; and positive regulation of actin filament polymerization. Located in cytoplasm and filopodium tip. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; gut section; muscle cell; and myoblast. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1); WIPF2 (WAS/WASL interacting protein family member 2); and WIPF3 (WAS/WASL interacting protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22106107..22122562, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17993612..18010067, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed

Names: CG13503-PA; CG13503-PB; CG13503-PC; CG13503-PD; CG13503-PE; CG13503-PF; CG13503-PG; CG13503-PH; CG13503-PI; CG13503-PJ; CG13503-PK; CG13503-PL; D-WASp-interacting protein; Verprolin1; Vrp1-PA; Vrp1-PB; Vrp1-PC; Vrp1-PD; Vrp1-PE; Vrp1-PF; Vrp1-PG; Vrp1-PH; Vrp1-PI; Vrp1-PJ; Vrp1-PK; Vrp1-PL; WASP-interacting protein; WASp interacting protein; drosophila WIP; solitary; veroprolin; verprolin