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    nlpE sensor lipoprotein NlpE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946782, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nlpE
    Official Full Name
    sensor lipoprotein NlpE
    Primary source
    ECOCYC:EG12137
    Locus tag
    b0192
    See related
    ASAP:ABE-0000652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cutF; ECK0192
    Summary
    NlpE is an outer membrane lipoprotein . [More information is available at EcoCyc: EG12137].
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    Genomic context

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    Sequence:
    NC_000913.3 (215269..215979)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene modulator of Rho-dependent transcription termination Neighboring gene PF06786 family protein YaeP Neighboring gene uncharacterized protein YaeQ Neighboring gene peptidyl-tRNA hydrolase, ribosome rescue factor Neighboring gene peptidase C92 family protein YaeF Neighboring gene proline--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane. May KL, et al. mBio, 2019 May 28. PMID 31138744, Free PMC Article
    2. Redefining the essential trafficking pathway for outer membrane lipoproteins. Grabowicz M, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28416660, Free PMC Article
    3. The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion. Shimizu T, et al. Infect Immun, 2016 Feb. PMID 26644384, Free PMC Article
    4. Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli. Hirano Y, et al. Structure, 2007 Aug. PMID 17698001
    5. The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways. Connolly L, et al. Genes Dev, 1997 Aug 1. PMID 9271123, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NlpE activates Cpx to protect against lipoprotein trafficking stress
      Title: A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane.
    2. Overall, these data demonstrate that NlpE acts as a sentinel for two important envelope biogenesis processes, namely, lipoprotein sorting and oxidative folding, and they further establish NlpE as a bona fide member of the CpxA-CpxR two-component system.
      Title: The Lipoprotein NlpE Is a Cpx Sensor That Serves as a Sentinel for Protein Sorting and Folding Defects in the Escherichia coli Envelope.
    3. Sensing of adhesion signals via NlpE is important for regulation of the expression of the type III secretion system and flagella in enterohemorrhagic Escherichia coli during infection
      Title: The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.
    4. The nonlipidated Cys1Ala mutant of NlpE with a C-terminal His tag from Escherichia coli was constructed, overexpressed and purified. The tetragonal crystals diffracted to 2.8 A resolution and belong to space group P4(3)2(1)2.
      Title: Purification, crystallization and preliminary X-ray crystallographic analysis of the outer membrane lipoprotein NlpE from Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to cell envelope stress EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stress response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sensor lipoprotein NlpE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      215269..215979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414734.1 sensor lipoprotein NlpE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414734.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IF33
      Conserved Domains (1) summary
      PRK10523
      Location:1 → 233
      PRK10523; envelope stress response activation lipoprotein NlpE
    Nucleotide Protein
    Heading Accession and Version

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